TA306722 TTBK1 antibody

Rabbit Polyclonal TTBK1 Antibody

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0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse TTBK1

TA306722

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  • TA306722
  • TA306722

Product Description for TTBK1

Rabbit anti Human, Mouse TTBK1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for TTBK1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms BDTK, Brain-derived tau kinase, KIAA1855, Tau-tubulin kinase 1
Presentation Aff - Purified
Reactivity Hu, Ms
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5TCY1
Immunogen:
TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.
GeneID:
84630
Add. information Blocking peptide available: AP30969CP-N
Application ELISA.
Western blot: 1 – 2 μg/ml.
Immunohistochemistry on paraffin sections.
Background Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.
General Readings
  1. Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep;98(5):1573-84. PubMed PMID: 16923168.
  2. Sato S, Xu J, Okuyama S, et al. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J. Neurosci. 2008; 28:14511-21.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, mouse
Specificity
Specificity:
This antibody detects TTBK1. It is predicted to not cross-react with TTBK2.

Accessory Products

Proteins and/or Positive Controls

Proteins for TTBK1 (2 products)

Catalog No. Species Pres. Purity   Source  

TTBK1

TTBK1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TTBK1

TTBK1 Human
  Abnova Taiwan Corp.

Positive controls for TTBK1 (1 products)

Catalog No. Species Pres. Purity   Source  

TTBK1 overexpression lysate

TTBK1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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