NB120-869 TTF1 antibody

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Mouse anti Human, Mouse, Rat TTF1 8G7G3/1


Product Description for TTF1

Mouse anti Human, Mouse, Rat TTF1 8G7G3/1.
Product is tested for Frozen Sections, Western blot / Immunoblot, Paraffin Sections.

Properties for TTF1

Product Category Primary Antibodies
Quantity 0.5 ml
Reactivity Hu, Ms, Rt
Applications C, P, WB
Clonality Monoclonal
Clone 8G7G3/1
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rat TTF 1 recombinant protein.
Background TTF 1(Thyroid transcription factor 1) is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. TTF 1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas. Staining with TTF 1 antibody is useful for distinguishing between tumors of lung and nonlung origin.
Concentration 0.2 mg/ml
General Readings This product has been used in:Fabbro D et al. TTF-1 gene expression in human lung tumours. Eur J Cancer 32A:512-7 (1996). PubMed PMID: 8814700
Holzinger A et al. Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis. Hybridoma 15:49-53 (1996). PubMed PMID: 9064286
General / background references:Di Loreto C et al. TTF-1 protein expression in pleural malignant mesotheliomas and adenocarcinomas of the lung. Cancer Lett 124:73-8 (1998). PubMed PMID: 9500194
Di Loreto C et al. Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol 50:30-2 (1997). PubMed PMID: 9059352
Zannini M et al. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J 16:3185-97 (1997). PubMed PMID: 9214635
Stahlman MT et al. Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung. J Histochem Cytochem 44:673-8 (1996). PubMed PMID: 8675988
Bejarano PA et al. Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol 9:445-52 (1996). PubMed PMID: 8729987
Storage Store at 4C. Do not freeze.
Tissue culture supernatant
Buffer System:
PBS. pH 7.4 with 0.2% BSA
Tissue culture supernatant
Cross-reacts with Human, Mouse, Rat and a wide range of other species.Not yet tested in other species.

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