discontinued

GTX11270 Tubulin antibody

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0.2 ml / €470.00

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Rabbit anti Chicken Tubulin

GTX11270

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  • GTX11270

Product Description for Tubulin

Rabbit anti Chicken Tubulin.
Presentation: Serum
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Tubulin

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Serum
Reactivity Chk
Applications ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Protein purified from 13 day old chicken embryos.
Application IF, WB
Background The major building block of microtubules is tubulin, an intracellular cylindrical filamentous structure that is present in almost all eukaryotic cells. Except in the simplest eukaryotes, tubulin (100 kDa) exists in all cells as a heterodimer of two similar but non-identical polypeptides (55 kDa each), designated alpha and beta, that assemble into microtubules. Within either family of alpha/beta tubulin heterodimers, individual subunits diverge from each other (both within and across species) at less than 10% of the amino acid positions. The most extreme diversity is localized to the carboxyl-terminal 15 residues. Both alpha and beta tubulins consist of various isotypes. In addition, both undergo post-translational modifications, including acetylation, phosphorylation detyrosination, polyglutamylation, and polyglycylation. Polyglutamylation of tubulin consists of the addition of a lateral chain of glutamyl units on the C-terminal region of tubulin polypeptides. This modification was shown to regulate the interaction between tau, one of the major neuronal microtubule associated proteins, and tubulin. Furthermore, it was shown that injection of monoclonal antibodies specific to the polyglutamylated form of tubulin into HeLa cells caused the disappearance of centrioles, an organelle known to have the most stable microtubules. The detection, localization, and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis, organellar and flagellar movement, intracellular transport, and cytoskeletal functions. Antibodies reacting specifically with the modified forms of alpha and beta tubulin isotypes serve as essential tools in the detection and study of the functional significance of these molecules.
Storage Aliquot and store at -20
Format
Purification:
Whole antiserum
Buffer System:
Preservative: 0.1% Sodium Azide
Purity:
Whole antiserum
State:
Serum
Specificity
Specificity:
Cross-reacts with Chicken. Not yet tested in other species.

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