discontinued

GTX11325 Tubulin antibody

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0.1 ml / €290.00

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Mouse anti Canine, Monkey, Mouse Tubulin TUB-1A2

Product Description for Tubulin

Mouse anti Canine, Monkey, Mouse Tubulin TUB-1A2.
Presentation: Ascites
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Tubulin

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Ascites
Reactivity Can, Mky, Ms
Applications ICC/IF, WB
Clonality Monoclonal
Clone TUB-1A2
Host Mouse
Isotype IgG3
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide containing the carboxy terminal amino acids of alpha tubulin.
Application IF, WB
Background Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement, and in the cytoskeleton. Tubulin is a heterodimer which consists of alpha tubulin and beta tubulin; both subunits have a molecular weight of 55 kDa and share considerable homology. The most widely studied tubulins have been isolated from vertebrate brains. The microtubules can be viewed in immunofluorescent microscopy allowing for the observation of the intracellular organization of proteins that are in the form of a supramolecular structure. Distinct classes of interphase microtubules have been described in tissue culture cells. They contain post translationally modified subunits of tubulin, detyrosinated alpha tubulin (Glutubulin) or acetylated alpha tubulin. The dynamic properties of microtubules of the Tyrtubulin type studied in living cells have suggested that they turnover and grow very rapidly in vivo with most microtubules exchanging within a half-time of approximately 10 minutes. Minor subpopulations of interphase microtubules have been found to be more stable in that they resist exchange for several hours, or that they are less sensitive to microtubule disrupting drugs. The coding portion of genes encoding alpha tubulin terminates in a tyrosine codon indicating that the primary gene product is tyrosinated (Tyr-Tu). Tubulin tyrosinylation is involved in the assembly status of tubulin. A specific tubulinyl tyrosine carboxypeptidase removes the terminal tyrosine to yield an alpha tubulin terminating in a glutamic acid residue while another enzyme modifies the alpha tubulin by addition of tyrosine to the carboxy terminus to offer a potential cycle of tyrosine addition and loss.
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Ascites
Buffer System:
Preservative: 0.1% Sodium Azide; Constituents: Ascites fluid.
Purity:
Ascites
State:
Liquid
Ascites
Specificity
Specificity:
Cross-reacts with tyrosine tubulin from the following sources: bovine brain, African Green Monkey kidney cells (Vero), dog kidney (MDCK), marsupial kidney (Potoroo, PtK2), mouse pituitary tumor (AtT-20), yeast, and Xenopus. Not yet tested in other species.

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