DM3604P TWSG1 / Tsg antibody

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0.1 mg / €460.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rat anti Mouse TWSG1 / Tsg 7D19


Product Description for TWSG1 / Tsg

Rat anti Mouse TWSG1 / Tsg 7D19.
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for TWSG1 / Tsg

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Twisted gastrulation protein homolog 1
Presentation Purified
Reactivity Ms
Applications C, WB
Clonality Monoclonal
Clone 7D19
Host Rat
Isotype IgG2
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Purified Mouse Recombinant TSG
Application Western Blot: 1/500-1/1000.
Immunohistochemistry on Frozen Sections: 1/50-1/200.
Background Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG was originally identified in Drosophila melanogaster and shown to be required for the differentiation of the dorsal amnioserosa cells. Studies of expression and function of Twisted Gastrulation have been performed in Drosophila and Xenopus. Xenopus TSG is expressed in the ventral regions of the embryo during gastrulation, mimicking the BMP-4 expression pattern. TSG is expressed in dorsal cells of the blastoderm embryo, where there are also high levels of activity of Dpp and Screw. Vertebrate TSGs were subsequently cloned in mouse, human, zebrafish and frog. TSG acts as an agonist for BMP signaling by modulating the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. The N-terminal domain of TSG can bind BMP protein directly in vitro and shows BMP antagonist activity.
Storage Prior to reconstitution store at -70°C.
Following reconstitution store the antibody (in aliquots) at -20°C for 6 month.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein A/G Affinity Chromatography
Buffer System:
Lophilized purified (0.2 μm filtered) IgG fraction from Culture Supernatant
Restore with 200µl sterile PBS and the final concentration is 500µl/ml.
This antibody detects Mouse TSG. Other species not tested.
Gene ID 65960

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