discontinued

NB120-738 Tyrosinase antibody

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0.5 ml / €380.00

Quick Overview

Mouse anti Human Tyrosinase T311

Product Description for Tyrosinase

Mouse anti Human Tyrosinase T311.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Tyrosinase

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Aff - Purified
Reactivity Hu
Applications C, WB
Clonality Monoclonal
Clone T311
Host Mouse
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant full length protein.
Background Studies have shown tyrosinase to be a very specific marker for melanomas, not cross reacting with any other tumors or normal tissues tested Other studies have shown tyrosinase to be a more sensitive marker when compared to HMB-45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB-45. However, both tyrosinase and MART-1 negative staining was seen in those variants without an epidermal component. Unlike HMB-45, neither tyrosinase or MART-1 discriminates between activated or resting melanocytes. In conclusion, tyrosinase appears to be a superior melanoma marker when compared to HMB-45.
General Readings 1. Chen et al. Proc Natl Acad Sci USA 92: 8125, 1995 Jungbluth AA et al. T311--an anti-tyrosinase monoclonal antibody for the detection of melanocytic lesions in paraffin embedded tissues. Pathol Res Pract 196:235-42 (2000). PubMed: 10782467
Hofbauer GF et al. Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution. J Cutan Pathol 25:204-9 (1998). PubMed: 9609139
Kaufmann O et al. Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. Mod Pathol 11:740-6 (1998). PubMed: 9720502
Format
Purification:
Immunogen affinity purified
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Cross-reacts with Human. Not yet tested in other species.

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