discontinued

NB110-75103 ubiquitin-binding protein p62 antibody

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0.15 ml / €350.00

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Sheep anti Human ubiquitin-binding protein p62

NB110-75103

Product Description for ubiquitin-binding protein p62

Sheep anti Human ubiquitin-binding protein p62.
Presentation: Serum

Properties for ubiquitin-binding protein p62

Product Category Primary Antibodies
Quantity 0.15 ml
Presentation Serum
Reactivity Hu
Clonality Polyclonal
Host Sheep
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
A synthetic peptide as a part of sequestosome-1 (ubiquitin-binding protein p62, p60, EBIAP) conjugated to immunogenic carrier protein has been used as the immunogen.
Application immunohistochemistry , Western Blot 1:200 to 1:5000
Background FUNCTION: Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.; SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Nucleus. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.; TISSUE SPECIFICITY: Ubiquitously expressed.
General Readings
  1. Devergne O, et al. J. Virol. 70:1143-1153(1996).
  2. Joung I, et al. Proc. Natl. Acad. Sci. U.S.A. 93:5991-5995(1996).
  3. Stumptner C, et al. Am. J. Pathol. 154:1701-1710(1999).
  4. Vadlamudi R.K, et al. J. Biol. Chem. 271:20235-20237(1996).
  5. Hocking L.J, et al. J. Bone Miner. Res. 19:1122-1127(2004).
  6. Good D.A, et al. Bone 35:277-282(2004).
  7. Hocking L.J, et al. Hum. Mol. Genet. 11:2735-2739(2002).
  8. Ciani B, et al. J. Biol. Chem. 278:37409-37412(2003).
  9. Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
  10. Olsen J.V, et al. Cell 127:635-648(2006).
Storage Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1)
Format
Purification:
Whole antisera
Buffer System:
Lyophilised in PBS
Purity:
Whole antisera
State:
Serum
Specificity
Species:
Human. Other species not yet tested.

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