discontinued

AP05612PU-S Uracil-DNA glycosylase 2 / Cyclin-O (N-term) antibody

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Rabbit anti Human, Mouse, Rat Uracil-DNA glycosylase 2 / Cyclin-O

Product Description for Uracil-DNA glycosylase 2 / Cyclin-O

Rabbit anti Human, Mouse, Rat Uracil-DNA glycosylase 2 / Cyclin-O.
Properties: (N-term)
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Uracil-DNA glycosylase 2 / Cyclin-O

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms CCNO, Cyclin-like uracil-DNA glycosylase, UDG2, UNG2
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P22674
Immunogen:
14 amino acid peptide sequence near the amino terminus of human UNG2.
GeneID:
10309
Property N-term
Application Western blot: 0.5 - 2.0 µg/ml; detects a band of approximately 38kDa in mouse bladder tissue lysate.
Background Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG2 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG2 is also essential to the generation of strand breaks that initiate class switch recombination.
UNG2 is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.
Caution (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Concentration 1.0 mg/ml
General Readings
  1. Hagen, L. et al. (2006) Genomic uracil and human disease. Exp. Cell Res. 312:2666 - 2672.
  2. Krokan, H. et al. (2001) Properties and functions of human uracilDNA glycosylase from the UNG gene. Prog. Nucleic Acid Res. Mol. Biol. 68:365 - 386.
Storage Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
Phosphate buffered saline containing 0.02% Sodium Azide
State:
Liquid purified IgG
Purified
Specificity
Specificity:
This antibody recognises uracil DNA glycosylase 2 (UNG2), a 38 kDa member of the cyclin family, expressed in the nucleus.
Species:
Human, Mouse, Rat.
Gene ID 10309

Accessory Products

Proteins and/or Positive Controls

Positive controls for Uracil-DNA glycosylase 2 / Cyclin-O (1 products)

Catalog No. Species Pres. Purity   Source  

CCNO overexpression lysate

CCNO overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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