AP01435PU-N Vasopressin V2 receptor (AVPR2) antibody

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0.1 mg / €350.00
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Rabbit anti Human Vasopressin V2 receptor (AVPR2)

Product Description for Vasopressin V2 receptor (AVPR2)

Rabbit anti Human Vasopressin V2 receptor (AVPR2).
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Vasopressin V2 receptor (AVPR2)

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms ADHR, AVPR V2, Antidiuretic hormone receptor, DIR, DIR3, Renal-type arginine vasopressin receptor, V2R
Presentation Aff - Purified
Reactivity Hu
Applications ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~38 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P30518
GeneID:
554
Application Western Blot: 1/500-1/1000.
Immunofluorescence: 1/50-1/200.
Background Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality. AVP mediates its effects through a family of G-protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion. It is detected as a full length protein and a shorter protein, which results from proteolytic cleavage of its amino terminus. The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration. The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney. Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP. The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system. The AVP Receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores. AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate Buffered Saline (PBS), pH~7.2 with 0.05% Sodium Azide as preservative.
State:
Liquid purified Ig fraction (> 95% by SDS-PAGE).
Aff - Purified
Specificity
Specificity:
This antibody detects endogenous levels of AVP Receptor V2 protein.(region surrounding Leu111)
Species:
Human.
Gene ID 554

Accessory Products

Proteins and/or Positive Controls

Positive controls for Vasopressin V2 receptor (AVPR2) (2 products)

Catalog No. Species Pres. Purity   Source  

AVPR2 Lysate

Western Blot: AVPR2 Lysate [NBL1-07867] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for AVPR2 Protein
  Novus Biologicals Inc.

AVPR2 overexpression lysate

AVPR2 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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