TA506222 VHL antibody

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0.1 ml / €379.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human VHL OTI1E1

TA506222

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Product Description for VHL

Mouse anti Human VHL OTI1E1.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for VHL

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Protein G7, Von Hippel-Lindau disease tumor suppressor
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone OTI1E1
Host Mouse
Isotype IgG2b
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P40337-2
Immunogen:
Full length human recombinant protein of human VHL(NP_000542) produced in HEK293T cell.
GeneID:
7428
Isotype control AM03110PU-N, SM12P
Application WB 1:4000
IHC 1:150
Background Von Hippel-Lindau syndrome (VHL) is a domintly inherited familial cancer syndrome predisposing to a variety of malignt and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitition and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. R polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Altertively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Format
Purification:
Purified from mouse ascites fluids by affinity chromatography
Buffer System:
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
State:
Purified

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