NBP1-22842 Vimentin antibody

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6 ml / €360.00

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Rabbit anti Human Vimentin SP20


Product Description for Vimentin

Rabbit anti Human Vimentin SP20.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Vimentin

Product Category Primary Antibodies
Quantity 6 ml
Synonyms anti-FLJ36605 antibody, anti-OTTHUMP00000019224 antibody, anti-VIM antibody, anti-vimentin antibody
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone SP20
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant human vimentin protein.
Add. information Intended Use: This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients
Application immunohistochemistry, Immunohistochemistry-Paraffin, This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded and acetone fixed cryostat tissue sections. No further titration is required., immunohistochemistry , Immunohistochemistry-Paraffin
Background Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain-dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared with carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognizing cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
No Preservative
IgG purified
This recognizes vimentin, the main intermediate filament protein in mesenchymal cells. It is of value in the differential diagnosis of undifferentiated neoplasms.

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