NBP1-22629 Vinculin (V284) antibody

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Mouse anti Human, Rabbit Vinculin (V284) V284


Product Description for Vinculin (V284)

Mouse anti Human, Rabbit Vinculin (V284) V284.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for Vinculin (V284)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-MVCL antibody, anti-Metavinculin antibody, anti-VCL antibody, anti-VINC antibody
Presentation Supernatant
Reactivity Hu, Rb
Applications P
Clonality Monoclonal
Clone V284
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Vinculin derived from human platelets.
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:50
Background Vinculin is a cytoskeletal protein associated with the cytoplasmic faces of both cell-cell and cell extracellular matrix adherens type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. The sequences of chicken, nematode and human vinculin have been determined. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha actinin and possibly with itself. Since alpha actinin binds to and cross links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system.
Storage Store at 4C. Do not freeze.
Tissue culture supernatant
Buffer System:
Sodium Azide
Tissue culture supernatant
This antibody recognizes human vinculin, a 130 kD protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin is widely distributed in tissues and co-expresses where smooth muscle actin and fibroblasts attach to the extracellular matrix. This antibody cross reacts with rabbit vinculin.
Human, Rabbit

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