discontinued

AP55466PU-N VNN3 (C-term) antibody

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0.1 mg / €360.00

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Rabbit anti Human, Mouse, Rat VNN3

AP55466PU-N

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  • AP55466PU-N

Product Description for VNN3

Rabbit anti Human, Mouse, Rat VNN3.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for VNN3

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms HSA238982, Vanin 3, Vascular non-inflammatory molecule 3
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Molecular weight 55 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
B2DFY0
Immunogen:
19 amino acid synthetic peptide near the carboxy terminus of Human VNN3 (AP55466CP-N)
GeneID:
55350
Property C-term
Add. information Blocking peptide available: AP55466CP-N
Application Western blot: 0.5-1 µg/ml. 
Positive Control: Human brain tissue lysate.
Background The vanin family is a novel group of ectoenzymes that function in tissue repair and plays a role in oxidative-stress response. As both secreted and membrane proteins, the vanin family members have been implicated as therapeutic targets in inflammatory disease. VNN3 (vascular non-inflammatory molecule 3), also known as Vanin3, is a 501 amino acid GPI-anchored amidohydrolase that is widely expressed and is found at highest levels in blood and liver. Induced by Th17 / Th1 type cytokines, VNN3 converts pantetheine into pantothenic acid. Containing one CN hydrolase domain, VNN3 is encoded by a gene that maps to human chromosome 6q23.2.
Concentration 1.0 mg/ml
General Readings
  1. Granjeaud S, Naquet P, Galland F. An ESTs description of the new Vanin gene family conserved from fly to human. Immunogenetics. 1999 Oct;49(11-12):964-72. PubMed PMID: 10501839.
  2. Jansen PA, Kamsteeg M, Rodijk-Olthuis D, van Vlijmen-Willems IM, de Jongh GJ, Bergers M, et al. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. J Invest Dermatol. 2009 Sep;129(9):2167-74. doi: 10.1038/jid.2009.67. Epub 2009 Mar 26. PubMed PMID: 19322213.
  3. Nitto T, Inoue T, Node K. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. Gene. 2008 Dec 15;426(1-2):57-64. doi: 10.1016/j.gene.2008.08.019. Epub 2008 Sep 5. PubMed PMID: 18805469.
  4. Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, et al. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics. 2001 May-Jun;53(4):296-306. PubMed PMID: 11491533.
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat.
Specificity
Specificity:
Multiple isoforms of VNN3 are known to exist.

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