TA326875 WAS / IMD2 antibody

WAS Rabbit Polyclonal Antibody

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Search for all "WAS / IMD2"

0.1 mg / €335.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat WAS / IMD2

TA326875

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  • TA326875
  • TA326875

Product Description for WAS / IMD2

Rabbit anti Human, Mouse, Rat WAS / IMD2.
Presentation: Purified

Properties for WAS / IMD2

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms WASp, Wiskott-Aldrich syndrome protein
Presentation Purified
Reactivity Hu, Ms, Rt
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P42768
Immunogen:
Recombinant protein of human WAS.
GeneID:
7454
Application WB 1:500 - 1:2000
IHC 1:50- 1:200
Background Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dymics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac . Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neurol defects and embryonic lethality . Loss of WASP results in immune system defects and fewer immune cells . WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain . WAVE-3 may act as a tumor suppressor in neuroblastoma, a childhood disease of the sympathetic nervous system . Increased expression of WAVE-3 is seen in breast cancer, and studies in breast adenocarcinoma cells indicate that WAVE-3 regulates breast cancer progression, invasion and metastasis through the p38 mitogen-activated protein kise (MAPK) pathway .
Format
Purification:
Affinity purification
Buffer System:
Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for WAS / IMD2 (3 products)

Catalog No. Species Pres. Purity   Source  

WAS / IMD2

WAS / IMD2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

WAS / IMD2

WAS / IMD2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

WAS / IMD2

WAS / IMD2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.
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