AP14648PU-N ZAK (C-term) antibody

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0.1 mg / €335.00

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Rabbit anti Human ZAK

Product Description for ZAK

Rabbit anti Human ZAK.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for ZAK

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms "Sterile-alpha motif and leucine zipper containing kinase AZK, Mixed lineage kinase-related kinase MRK-alpha"
Presentation Purified
Reactivity Hu
Applications P
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ZAK.
Property C-term
Application ELISA: 1/1,000.
Immunohistochemistry: 1/50 - 1/100.
Background This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration 0.25 mg/ml
General Readings
  1. Blume-Jensen P, et al. Nature 2001. 411: 355.
  2. Cantrell D, J. Cell Sci. 2001. 114: 1439.
  3. Jhiang S Oncogene 2000. 19: 5590.
  4. Manning G, et al. Science 2002. 298: 1912.
  5. Moller, D, et al. Am. J. Physiol. 1994. 266: C351-C359.
  6. Robertson, S. et al. Trends Genet. 2000. 16: 368.
  7. Robinson D, et al. Oncogene 2000. 19: 5548.
  8. Van der Ven, P, et al. Hum. Molec. Genet. 1993. 2: 1889.
  9. Vanhaesebroeck, B, et al. Biochem. J. 2000. 346: 561.
  10. Van Weering D, et al. Recent Results Cancer Res. 1998. 154: 271.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
Liquid purified Ig
This antibody reacts to ZAK.

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