discontinued

SP6269P ZIP Kinase (ZIPK) (279-298) antibody

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50 µg / €210.00

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Rabbit anti Human, Mouse, Rat ZIP Kinase (ZIPK) (279-298)

SP6269P

Product Description for ZIP Kinase (ZIPK) (279-298)

Rabbit anti Human, Mouse, Rat ZIP Kinase (ZIPK) (279-298).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for ZIP Kinase (ZIPK) (279-298)

Product Category Primary Antibodies
Quantity 50 µg
Synonyms DAP-kinase 3, DAP-like kinase, DLK, Death-associated protein kinase 3, ZIP-kinase
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-ZIP kinase (IN) polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 279 to 298 of human origin (1). Peptide available as SP6269CP.
Application Western blot: 1/1000. Jurkat or HeLa whole cell lysate can be used as positive control and a 52 kDa immunoreactive band should be detected. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings
  1. Kawai, T. et al. (1998). ZIP kinase, a novel serine/threonine kin
Storage Store the antibody at 4-8°C for one month or at -20°C for longer. This product should be stored undiluted. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format
State:
Aff - Purified
Specificity
Specificity:
This antibody recognises ZIP kinase in Western blots, detecting a band of 52kD.
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase (1). ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues (1).

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