SM1505P Equine IgGb antibody

Search for all "Equine IgGb"

0.1 mg / €400.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Product Description for Equine IgGb

Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Equine IgGb

Product Category Secondary Antibodies
Quantity 0.1 mg
Synonyms Horse IgGb
Presentation Purified
Reactivity Eq
Applications E
Clonality Monoclonal
Clone CVS39
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Purified Equine IgGb.
Spleen cells from immunised Balb/c mice were fused with cells of the mouse X63-Ag8.653 myeloma cell line.
Isotype control AM03095PU-N
Application ELISA.
Background Equine IgGb is an immunologlobulin with a molecular weight (MW) of approximately 160kDa, the MW of the light chain being 27kDa, common to all equine IgG subclasses, while the heavy chain has a MW of 53kDa, specific to IgGb (Sheoran et al. 1998). Equine IgGb has been demonstrated to be involved in long lasting immunity following respiratory-related viral infections such as Equine Herpes virus Type 4 (EHV-4) (Mizukoshi et al. 2002) and Equine Influenza (Soboll et al. 2003).
Concentration 1.0 mg/ml
General Readings
  1. Sheoran AS, Lunn DP, Holmes MA. Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet Immunol Immunopathol. 1998 Mar 31;62(2):153-65. PubMed PMID: 9638859.
  2. Lewis MJ, Wagner B, Woof JM. The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies. Mol Immunol. 2008 Feb;45(3):818-27. Epub 2007 Jul 31. PubMed PMID: 17669496. (Free PMC Article available, 8 images available)
  3. Keggan A, Freer H, Rollins A, Wagner B. Production of seven monoclonal equine immunoglobulins isotyped by multiplex analysis. Vet Immunol Immunopathol. 2013 Jun 15;153(3-4):187-93. doi: 10.1016/j.vetimm.2013.02.010. Epub 2013 Feb 19. PubMed PMID: 23541920.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography on Protein G
Buffer System:
0.09% Sodium Azide
Liquid purified IgG fraction from Tissue Culture Supernatant
Mouse anti Horse IgGb antibody, clone CVS39 recognizes Equine IgGb, recently classified as Equine IgG4/7 (Keggan et al. 2013), and shows no significant binding to other IgG subclasses.
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