AM26793PU-N Human IgD antibody

Search for all "Human IgD"

0.1 mg / €180.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

AM26793PU-N

Product Description for Human IgD

Presentation: Purified
Product is tested for Flow Cytometry.

Properties for Human IgD

Product Category Secondary Antibodies
Quantity 0.1 mg
Synonyms Human Immunoglobulin D
Presentation Purified
Reactivity Hu
Applications F
Clonality Monoclonal
Clone IA6-2
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human IgD
Isotype control AM03096PU-N
Application Flow cytometry.
Background Immunoglobulin D (IgD) is expressed on the surface of naive mature B cells, thus later than IgM, and is coexpressed with it then. Triggered by antigen binding, it signals through the CD79 complex to activate the B cells. Expression of IgD is lost after the isotype switch. Soluble IgD is present in very small amounts in the serum. IgD can bind to basophils and mast cells to activate them in an IgE-independent way to participate in respiratory immune defense.
Concentration 1.0 mg/ml
General Readings
  1. Bunch DO, McGregor JG, Khandoobhai NB, Aybar LT, Burkart ME, Hu Y, et al. Decreased CD5⁺ B cells in active ANCA vasculitis and relapse after rituximab. Clin J Am Soc Nephrol. 2013 Mar;8(3):382-91. doi: 10.2215/CJN.03950412. Epub 2013 Jan 4. PubMed PMID: 23293123. (Free PMC Article available, 3 images available)
  2. Baier G, Baier-Bitterlich G, Looney DJ, Altman A. Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J Virol. 1995 Apr;69(4):2357-65. PubMed PMID: 7533857. (Free PMC Article available)
  3. Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12614-9. PubMed PMID: 11675497. (Free PMC Article available, 5 images available)
  4. Di Sabatino A, Carsetti R, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, et al. Immunoglobulin M memory B cell decrease in inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2004 Sep-Oct;8(5):199-203. PubMed PMID: 15638230.
  5. Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA, et al. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest. 2001 Oct;108(7):1061-70. PubMed PMID: 11581307. (Free PMC Article available, 3 images available)
  6. Degauque N, Ngono AE, Akl A, Lepetit M, Crochette R, Giral M, et al. Characterization of antigen-specific B cells using nominal antigen-coated flow-beads. PLoS One. 2013 Dec 30;8(12):e84273. doi: 10.1371/journal.pone.0084273. eCollection 2013. PubMed PMID: 24386360. (Free PMC Article available, 6 images available)
  7. Chang NH, McKenzie T, Bonventi G, Landolt-Marticorena C, Fortin PR, Gladman D, et al. Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus. J Immunol. 2008 Jan 15;180(2):1276-84. PubMed PMID: 18178868.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Buffer System:
Phosphate buffered saline (PBS)
Preservatives:
15 mM sodium azide, approx. pH 7.4
State:
Liquid Ig fraction
Purified
Specificity
Specificity:
This antibody recognizes human Immunoglobulin D.
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