AM08095C5-N Rat IgM (Mu chain specific) antibody

Search for all "Rat IgM"

0.1 mg / €410.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

AM08095C5-N

Product Description for Rat IgM

Properties: (Mu chain specific)
Presentation: Cy5
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for Rat IgM

Product Category Secondary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Rat Immunoglobulin M
Presentation Cy5
Reactivity Rt
Applications F, ICC/IF
Clonality Monoclonal
Clone M 2A1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Flow Cytometry (< / = 0.3 µg/10e6 cells) and Immunofluorescence Microscopy: Identification and enumeration of IgM+ cells.
Background IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences.
Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type.
Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
Concentration 0.1 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Label:
Cyanine 5
Cy5
Buffer System:
PBS containing 0.09% Sodium Azide as preservative.
State:
Liquid purified Ig fraction.
Specificity
Specificity:
This antibody reacts with the Mu heavy chain (Fc) of Rat IgM.
Species:
Rat.
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