AGE – Advanced Glycation End Products - FocusOn 113

AGE and Ageing

Long term incubation of proteins with glucose can, through Schiff base and Amadori rearrangement, lead to the formation of Advanced Glycation End Products (AGE). Precipitates generated through crosslinking are recognizable by a characteristic brown colour and auto-fluorescence.

Using antibodies AGE has been found in human lens, in chronic nephropathic kidney and amyloidosis, in ateriosclerotic artery walls and in brain tissue from patients suffering from Morbus Alzheimer. These results suggest a potential role of AGE in ageing and associated diseases.

Receptors for AGE (RAGE)

RAGE, the receptor for AGE, is a surface transmembrane protein, which is able to recognize different AGE products. In normal tissue the expression of RAGE is low, but at sites of inflammation, diabetic complications, amyloidosis or in tumor tissue expression is upregulated. It has been shown, that activation of RAGE may lead to cellular dysfunction by means of formation and precipitation of AGE products.

In the table below antibodies for detection of  AGE and RAGE are listed.

All AGE/RAGE products: AGE antibody, RAGE antibody



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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AGE antibody

AGE Goat IgG Serum Hu E, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

AGE antibody

AGE Rabbit Serum E
0.2 ml / €430.00
  Acris Antibodies GmbH

AGE antibody

AGE Rabbit Aff - Purified Hu C, E
0.2 mg / €410.00
  Acris Antibodies GmbH

RAGE / AGER (N-term) antibody

RAGE / AGER Goat Serum Hu P
0.2 ml / €330.00
  Acris Antibodies GmbH

RAGE / AGER (42-59) antibody

RAGE / AGER Goat Serum Bov, Hu, Ms, Rt E, P, WB
0.1 ml / €540.00
  Acris Antibodies GmbH

RAGE / AGER (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

RAGE / AGER antibody

Immunohistochemical analysis of Paraffin-Embedded Rat Tissue Sections (Lung) using RAGE antibody. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €340.00
  Acris Antibodies GmbH

RAGE / AGER (Extracell. Dom.) antibody

RAGE / AGER Rat IgG2 2B65 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

RAGE / AGER (42-59) antibody

RAGE / AGER Goat Serum Bov, Can, Chimp, Hu, Mky, Ms, Por, Rb, Rt E, FN, P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

9 Item(s)

per page
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