Antibodies to Adenosine Receptors - FocusOn 065
Antibody tools for the detection of adenosine receptor subtypes
Acris Antibodies offers a panel of antibodies to adenosine receptors. These antibodies are suitable for immunological detection methods like immunohistochemistry and Western blotting. A choice of our antibodies to different adenosine receptor subtypes is shown in ‘Product list’.
The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis.
Adenosine released from cells interacts with membrane receptors (Adenosine receptors, ARs, ADORs). Based upon biochemical and pharmacological criteria ARs have been classified into A1, A2a, A2b, and A3. The high affinity receptor A1 inhibits adenyl cyclase, whereas low affinity receptor A2a stimulates the cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in the coronary artery. Various ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and are predicted to contain seven transmembrane domains. The N-termini are predicted to be extracellular and the C-termini cytoplasmic. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: ADORA1 (Chromosome 1; q.31.3-32.2), ADORA2a (Chromosome 22, ADORA2b (Chromosome 17; p.11.2-12), ADORA3 (Chromosome 1).
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