Antibodies to Androgen Receptor - FocusOn 052

Introduction

Androgens are steroid hormones that are necessary for normal male phenotype expression, including the outward development of secondary sex characteristics as well as the initiation and maintenance of spermatogenesis.

Many physiological actions of androgens are mediated by the androgen receptor (AR). AR functions as a ligand-dependent transcription factor, regulating expression of an array of target genes that are important in male pubertal development and fertility.

The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide responsive gene products for differentiation and growth, but under abnormal conditions it contributes to the development of prostate cancer.

AR is a 110 kD protein and a member of the steroid/nuclear receptor gene superfamily. The PI3K/Akt pathway regulates AR activity by inducing its phosphorylation at Ser210 and Ser790.

Antibody Tools for the Detection of Androgen Receptor

Acris Antibodies offers a panel of monoclonal and polyclonal antibodies for the detection of androgen receptor in several species. Antibodies can be used for immunohistochemistry, western blotting and other immunologicals methods.

Staining of human prostate using DM245P. Note nuclear staining of glandular epithelial cellsStaining of primate brain sections using SM5020P 

Fig.1: Formalin-fixed, paraffin-embedded human prostate stained with Androgen Receptor antibody AM00244PU-N

Fig.2: Staining of primate brain section using Androgen Receptor antibody SM5020P

Available Antibody Panel to Androgen Receptor

Anti- Androgen Receptor (Dihydrotestosterone Receptor, DHTR, NR3C4)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Androgen receptor antibody

Human prostate ca. stained with Anti-AR antibody Rabbit Purified Hu, Ms, Rt ICC/IF, IP, P, WB
1 ml / €520.00
  Acris Antibodies GmbH

Androgen receptor antibody

Human prostate ca. stained with Anti-AR antibody Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €190.00
  Acris Antibodies GmbH

Androgen receptor pSer213 antibody

Immunohistochemistry (IHC) analysis of p-Androgen Receptor antibody (Cat.-No.: AP01524PU-N) in paraffin-embedded human prostate carcinoma tissues Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

Androgen receptor pSer650 antibody

Immunohistochemistry (IHC) analysis of p-Androgen Receptor (pSer650) antibody (Cat.-No.: AP01525PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

Androgen receptor antibody

Androgen receptor Rabbit IgG Purified P
1 ml / €440.00
  Acris Antibodies GmbH

Androgen receptor antibody

Immunohistochemical analysis using Androgen receptor antibody (Cat.-No. AP06010PU-N) in Paraffin-embedded human prostate carcinoma tissue. Rabbit Aff - Purified Hu E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

Androgen receptor antibody

Immunohistochemical analysis using Androgen receptor  antibody (Cat.-No. AP06011PU-N) in Paraffin-embedded human prostate carcinoma tissue. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Androgen receptor pSer213 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa
cells using Androgen Receptor (phospho-Ser213)
antibody (#AP08008PU). Rabbit Aff - Purified Hu ICC/IF, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Androgen receptor pSer213 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa
cells using Androgen Receptor (phospho-Ser213)
antibody (#AP08008PU). Rabbit Aff - Purified Hu ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

Androgen receptor pSer650 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Androgen Receptor pSer650 antibody (AP08009PU). Rabbit Aff - Purified Hu P
0.1 ml / €320.00
  Acris Antibodies GmbH

Androgen receptor pSer650 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Androgen Receptor pSer650 antibody (AP08009PU). Rabbit Aff - Purified Hu P
50 µl / €240.00
  Acris Antibodies GmbH

Androgen receptor antibody

Western blot analysis of extracts from Rat testis tissue using Androgen Receptor antibody AP09465PU Rabbit Aff - Purified Hu WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Androgen receptor antibody

Western blot analysis of extracts from Rat testis tissue using Androgen Receptor antibody AP09465PU Rabbit Aff - Purified Hu WB
50 µl / €230.00
  Acris Antibodies GmbH

Androgen receptor (N-term) antibody

Androgen receptor Mouse IgG1 F39.4 Purified Hu C, ICC/IF, P, WB
1 ml / €340.00
  Acris Antibodies GmbH

Androgen receptor antibody

Formalin fixed paraffin embedded human prostate stained with Androgen Receptor antibody DM245 Mouse IgG1 AR441 Purified Can, Hu C, P, WB
1 ml / €640.00
  Acris Antibodies GmbH

Androgen receptor antibody

Formalin fixed paraffin embedded human prostate stained with Androgen Receptor antibody DM245 Mouse IgG1 AR441 Purified Can, Hu C, P, WB
0.5 ml / €420.00
  Acris Antibodies GmbH

Androgen receptor (N-term) antibody

Androgen Receptor antibody [N1], N-term detects Androgen Receptor protein at nucleus on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. Androgen Receptor antibody [N1], N-term (GTX100056) dilution: 1:500. Rabbit Aff - Purified Hu WB
0.1 ml / €350.00
  GeneTex Inc.


Sample size available for 25µl / 119€
read more…

Androgen receptor antibody

Formalin-fixed and paraffin-embedded human hepatocellular cancer tissue reacted with AR polyclonal antibody ( Cat # PAB1939 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

Androgen receptor antibody

AR polyclonal antibody ( Cat # PAB6663 ) ( 0.3 µg/ml ) staining of human brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Androgen receptor antibody

Imunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using AR (phospho S650) polyclonal antibody ( Cat # PAB7733 ). Rabbit Hu P
0.1 mg / €400.00
  Abnova Taiwan Corp.

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