Antibodies to Dopamine, Dopamine- hydroxylase (DBH), Dopamine-transporter and -receptors - FocusOn 090

Introduction

Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intra cellular ion transport. For example, degeneration of certain dopamine-producing brain cells results in parkinsonism.

A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). The two isoforms of D2R, D2 long (D2L) and short D2S, are encoded by splice variants of a single gene and differ only by the presence of an additional 29 aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains.

Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is expressed selectively in noradrenergic and adrenergic neurons in the nervous system.

The dopamine transporter (DAT) is a phosphoprotein whose activity and phosphorylation state are acutely regulated by both protein kinase C (PKC) and substrate transport. DAT is a major site of action for psychostimulant and therapeutic drugs that either block transport or are transported substrates.

Antibody Panel to Dopamine, DBH, Dopamine-transporter and Its Receptors

Acris Antibodies offers a range of monoclonal and polyclonal antibodies to to Dopamine and its beta-hydroxylase, transporter and receptors suitable for Immunohistochemical applications and / or Western blotting.

AP15518PU-N Dopamine receptor D2 antibody staining of Human Brain.SP4562P

Fig. 1: AP15518PU-N Dopamine receptor D2 antibody staining of Human Brain.

Fig. 2: SP4562P Dopamine receptor D2 antibody staining of Human Brain Sections (Neurons and glia).

Antibody Panel to Dopamine, DBH, Dopamine-transporter and Its Receptors

Dopamine (D1-D5), DBH, Dopamine-transporter (DATs) and its Receptors antibody.

Literature

Cervinski MA, Foster JD, Vaughan RA.Psychoactive substrates stimulate dopamine transporter phosphorylation and down regulation by cocaine sensitive and protein kinase C dependent mechanisms. 2005 Dec 9;280(49):40442-9.

Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL.In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys.Synapse. 2005 Dec 15;58(4):220-8.

Gorentla BK, Vaughan RA.Differential effects of dopamine and psychoactive drugs on dopamine transporter phosphorylation and regulation.Neuropharmacology. 2005 Nov;49(6):759-68.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dopamine antibody

Dopamine Mouse IgG2b DA.2B11 Purified E, ICC/IF
0.1 mg / €350.00
  Acris Antibodies GmbH

Dopamine antibody

Dopamine Mouse IgG1 2B11 Purified E, FN, ICC/IF
1 mg / €340.00
  HyTest Ltd.

Dopamine beta-hydroxylase antibody

Dopamine beta-hydroxylase Mouse IgG1 4F9/9 Ascites Bov, Hu, Rt C, ICC/IF, P
0.1 ml / €710.00
  Acris Antibodies GmbH

Dopamine D2 receptor (Short Isoform, 239-246) antibody

Dopamine D2 receptor Rabbit Serum Rt C, E, ICC/IF, WB
0.1 ml / €520.00
  Acris Antibodies GmbH

Dopamine D2 receptor (long isoform, 243-254) antibody

Dopamine D2 receptor Rabbit Serum Hu, Rt C, E, ICC/IF, WB
0.1 ml / €520.00
  Acris Antibodies GmbH

Dopamine D3 Receptor Control Peptide

Dopamine D3 Receptor
0.25 mg / €250.00
  Acris Antibodies GmbH

Dopamine D3 Receptor (N-term) antibody

Western blot using AP09967PU-N (1:750). Rabbit Aff - Purified Hu, Ms, Rt Dot, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Dopamine D4 receptor (C-term)

Dopamine D4 receptor
0.25 mg / €250.00
  Acris Antibodies GmbH

Dopamine D4 receptor (C-term) antibody

High magnification of rat brain section stained with AP09968PU-N  at 1:250. Rabbit Aff - Purified Hu, Ms, Rt Dot, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Dopamine D4 receptor (Center) antibody

Western blot analysis of DRD4 Antibody (Center) (AP17995PU-N) in mouse heart tissue lysates (35ug/lane). DRD4 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Dopamine D4 receptor antibody

Dopamine D4 receptor Rabbit Serum Hu, Rt C, E, ICC/IF, WB
0.1 ml / €520.00
  Acris Antibodies GmbH

Dopamine D5 receptor (459-477) antibody

AP15518PU Dopamine receptor D2 antibody staining of Human Brain. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Dopamine D5 receptor Control Peptide

Dopamine D5 receptor
0.25 mg / €250.00
  Acris Antibodies GmbH

Dopamine D5 receptor (C-term) antibody

Western blot using AP09969PU-N. Rabbit Aff - Purified Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SLC6A3 / DAT (N-term) antibody

SLC6A3 / DAT Rat IgG2a 4F8 Supernatant Hu, Mky, Ms, Rt C, WB
0.1 ml / €500.00
  Acris Antibodies GmbH

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