Antibodies to Endothelial Differentiation Gene Receptors (EDG-1,-2,-4,-5,-6,-7 and -8) - FocusOn 093
Introduction
Lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and some other structurally related lysophospholipids are active growth factors and stimuli for diverse cellular functions.
LPA and S1P promote early T cell migration to tissue sites of immune responses and regulate T cell proliferation and secretion of numerous cytokines. The endothelial differentiation gene (EDG) receptors are a class of G protein-coupled receptors. EDG-1, -3, -5, -6, and -8 (known as the endothelial differentiaton gene-1 family) regulate diverse processes including cell migration, angiogenesis, vascular maturation, heart development, neurite retraction and soma rounding. These receptors bind the bioactive lipid sphingosine-1-phosphate (S1P) as the primary signaling ligand. EDG-2, -4, and -7 bind the ligand lysophosphatidic acid.
Antibody Panel to EDG Receptors
Acris Antibodies offers a wide range of polyclonal antibodies to EDG-receptors suitable for Immunohistochemistry (on Paraffin-embedded tissues) and Western blotting.
![]() | ![]() |
Fig.1: Immunohistochemical staining of heart vessel using antibody Cat.No. SP4617P (anti-EDG-1)
Fig.2: Immunohistochemical staining of brain neurons and glia using antibody SP4371P (anti-EDG-2)
![]() | ![]() |
Fig.3: Immunohistochemical staining of breast carcinoma using antibody Cat.No. SP4498P (anti-EDG-5)
Fig.4:Immunohistochemical staining of lymph node using antibody Cat.No. SP4500 (anti-EDG-6)
![]() | ![]() |
Fig.5: Immunohistochemical staining of amygdala using antibody Cat.No. SP4375P (anti-EDG-7)
Fig.6: Immunohistochemical staining of neurons and glia in rat brain using antibody Cat.No SP4501 (anti-EDG-8)
Antibody Panel to
Endothelial Differentiation Gene Receptors (EDG-1,-2,-4,-5,-6,-7 and -8) antibody.
Literature
Kohno T, Igarashi Y.Roles for N-glycosylation in the dynamics of EDG-1/S1P1 in sphingosine 1-phosphate stimulated cells.Glycoconj J. 2004; 21(8-9): 497-501.
Laychock SG, Tian Y, Sessanna SM.Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells.Diabetes. 2003 Aug; 52(8): 1986-93.
Huang MC, Graeler M, Shankar G, Spencer J, Goetzl EJ.Lysophospholipid mediators of immunity and neoplasia.Biochim Biophys Acta. 2002 May 23; 1582(1-3): 161-7.
Toman RE, Milstien S, Spiegel S.Sphingosine-1-phosphate: an emerging therapeutic target.Expert Opin Ther Targets. 2001 Feb; 5(1): 109-23.
- Quick-Filters:
- Cited (5)
- Highly Validated (1)
- Overnight Delivery (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
---|---|---|---|---|---|---|---|
AP05083PU-N | EDG1 / S1P1 antibody |
||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€540.00
|
|
Acris Antibodies GmbH | |||||||
Published recently! |
|||||||
AP01197PU-N | EDG1 / S1P1 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu | ICC/IF, P, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
AP01462PU-N | EDG1 / S1P1 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
AP13100PU-N | EDG1 / S1P1 (N-term) antibody |
||||||
![]() |
Rabbit | Ig | Purified | Hu | P |
0.4 ml /
€370.00
|
|
Acris Antibodies GmbH | |||||||
AP01253PU-N | EDG2 / LPAR1 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Rt | P, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
|||||||
AP13101PU-N | EDG2 / LPAR1 (N-term) antibody |
||||||
![]() |
Rabbit | Ig | Purified | Hu | WB |
0.4 ml /
€370.00
|
|
Acris Antibodies GmbH | |||||||
AP01309PU-N | EDG3 / S1P3 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
AP01423PU-N | EDG3 / S1P3 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu | WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
AP05158PU-N | EDG3 / S1P3 antibody |
||||||
![]() |
Rabbit | Purified | Hu | WB |
0.1 mg /
€540.00
|
||
Acris Antibodies GmbH | |||||||
AP05159PU-N | EDG3 / S1P3 antibody |
||||||
![]() |
Rabbit | Purified | Hu | WB |
0.1 mg /
€540.00
|
||
Acris Antibodies GmbH | |||||||
AP07705PU-N | EDG3 / S1P3 antibody |
||||||
![]() |
Rabbit | Purified | Hu | E, P |
50 µg /
€380.00
|
||
Acris Antibodies GmbH | |||||||
AP13102PU-N | EDG3 / S1P3 (N-term) antibody |
||||||
![]() |
Rabbit | Ig | Purified | Hu, Ms | WB |
0.4 ml /
€370.00
|
|
Acris Antibodies GmbH | |||||||
AP05151PU-N | EDG4 / LPAR2 antibody |
||||||
![]() |
Rabbit | IgG | Purified | Hu | WB |
0.1 mg /
€540.00
|
|
Acris Antibodies GmbH | |||||||
Published recently! |
|||||||
AP01254PU-N | EDG4 / LPAR2 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
AP01310PU-N | EDG4 / LPAR2 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms | E, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
AP05151CP-N | EDG4 / LPAR2 control peptide |
||||||
![]() |
Purified |
50 µg /
€220.00
|
|||||
Acris Antibodies GmbH | |||||||
AP07706PU-N | EDG4 / LPAR2 (18-32) antibody |
||||||
![]() |
Rabbit | Purified | Hu | E, P |
50 µg /
€380.00
|
||
Acris Antibodies GmbH | |||||||
AP13103PU-N | EDG4 / LPAR2 (N-term) antibody |
||||||
![]() |
Rabbit | Ig | Purified | Hu | P, WB |
0.4 ml /
€370.00
|
|
Acris Antibodies GmbH | |||||||
![]() |
|||||||
SP4373P | EDG4 / LPAR2 (3rd Cytopl. Dom) antibody |
||||||
![]() |
Rabbit | Aff - Purified | Bear, Bov, Bt, Can, Elephant, Eq, Hu, Mky, Ms, Por, Prim, Rb, Rt | ICC/IF, P |
50 µg /
€380.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
|||||||
AP01198PU-N | EDG5 / S1P2 antibody |
||||||
![]() |
Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, P, WB |
0.1 mg /
€350.00
|
||
Acris Antibodies GmbH | |||||||
![]() |
Published recently! Highly validated antibody! |