Antibodies to Progesterone Receptor - FocusOn 049

Introduction

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone.

There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer.

The biological response to progesterone is mediated by two distinct forms of the progesterone receptor (A and B forms). Human PR consists of a 94 kDa A form and a 120 kDa B form. Chicken PR consists of a 78 kDa A form and a 110 kDa B form. In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.

Antibody Tools for the detection of Progesterone Receptor

Acris Antibodies offers a panel of antibodies to Progesterone receptor, suitable for immunological detection methods like immunohistochemistry, immunoprecipitation or Western blotting.

Fig. 1: Paraffin embedded human breast carcinoma sections stained with:
a) Cat.-No. DM103 (1 AEC staining)
b) Cat.-No. DRM002 (AEC staining)
 
Fig. 2: Polyclonal phosphospecific antibody Cat.-No. AP02372PU-N detects endogenous levels of Progesterone Receptor when phosphorylated at Serine 190 in various applications:
a) Western blot analysis of extract from SKOV3 cells untreated (lane 1) or treated with EGF (lane2) using Progesterone Receptor (pSer190) antibody
a) Western blot analysis of extract from SKOV3 cells untreated (lane 1) or treated with EGF (lane2) using Progesterone Receptor (pSer190) antibody
b) Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue, using Progesterone Receptor (pSer190) antibody
b) Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue, using Progesterone Receptor (pSer190) antibody
c) Immunofluorescence staining of methanol-fixed MCF cells using Progesteron Receptor (pSer190) antibody
c) Immunofluorescence staining of methanol-fixed MCF cells usingProgesteron Receptor (pSer190) antibody

Available antibody panel to PR

Progesterone receptor (PR, PGR, NR3C3 = Nuclear receptor subfamily 3 group C member 3) antibody

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Progesterone receptor (412-526) antibody

Human breast carcinoma
stained with anti-Progestrone
Receptor Rabbit SP42 Purified Hu P
1 ml / €1,010.00
  Acris Antibodies GmbH

Progesterone receptor (412-526) antibody

Human breast carcinoma
stained with anti-Progestrone
Receptor. Rabbit SP42 Purified Hu P

Regular Price: 0.1 ml / €250.00

Special Price: 0.1 ml / €175.00

  Acris Antibodies GmbH

Progesterone receptor (412-526) antibody

Human breast carcinoma
stained with anti-Progestrone
Receptor Rabbit SP42 Purified Hu P

Regular Price: 25 µl / €80.00

Special Price: 25 µl / €56.00

  Acris Antibodies GmbH

Progesterone receptor (412-526) antibody

AM11188PU Progesterone Receptor antibody staining of Human breast carcinoma. Rabbit SP2 Supernatant Hu P, WB
1 ml / €1,010.00
  Acris Antibodies GmbH

Progesterone receptor (412-526) antibody

AM11188PU Progesterone Receptor antibody staining of Human breast carcinoma. Rabbit SP2 Supernatant Hu P, WB

Regular Price: 0.1 ml / €250.00

Special Price: 0.1 ml / €175.00

  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded paraffin normal human breast carcinoma stained with Progesterone Receptor Antibody Cat.-No AM32853PU (Clone PR484). Mouse IgG1 PR484 Purified Hu C, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded paraffin normal human breast carcinoma stained with Progesterone Receptor Antibody Cat.-No AM32853PU (Clone PR484). Mouse IgG1 PR484 Purified Hu C, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded paraffin normal human breast carcinoma stained with Progesterone Receptor Antibody Cat.-No AM32853PU (Clone PR484). Mouse IgG1 PR484 Purified Hu C, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded Human Breast carcinoma stained with Progesterone Receptor Antibody Cat.-No AM32854PU (Clone PR500). Mouse IgG1 PR500 Purified Hu P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded Human Breast carcinoma stained with Progesterone Receptor Antibody Cat.-No AM32854PU (Clone PR500). Mouse IgG1 PR500 Purified Hu P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded Human Breast carcinoma stained with Progesterone Receptor Antibody Cat.-No AM32854PU (Clone PR500). Mouse IgG1 PR500 Purified Hu P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast stained with Progesterone Receptor Antibody Cat.-No AM32855PU (Clone PR501). Mouse IgG1 PR501 Purified Hu P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast stained with Progesterone Receptor Antibody Cat.-No AM32855PU (Clone PR501). Mouse IgG1 PR501 Purified Hu P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-Fixed, Paraffin-Embedded Human breast stained with Progesterone Receptor Antibody Cat.-No AM32855PU (Clone PR501). Mouse IgG1 PR501 Purified Hu P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Progesterone receptor Mouse IgG1 PR081 Supernatant Hu P
1.0 ml / €360.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Progesterone receptor Mouse IgG1 PR081 Supernatant Hu P
0.5 ml / €290.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Progesterone receptor Mouse IgG1 PR081 Supernatant Hu P
0.1 ml / €150.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-paraffin normal human breast carcinoma stained with Progesterone Receptor Antibody AM50154PU (Clone SPM566). Mouse IgG1 SPM566 Purified Hu C, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-paraffin normal human breast carcinoma stained with Progesterone Receptor Antibody AM50154PU (Clone SPM566). Mouse IgG1 SPM566 Purified Hu C, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Formalin-paraffin normal human breast carcinoma stained with Progesterone Receptor Antibody AM50154PU (Clone SPM566). Mouse IgG1 SPM566 Purified Hu C, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

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