Antibody Panel to ATM Kinase - FocusOn 072

Introduction

Ataxia-telangiectasia (A-T) is a recessive childhood disease caused by mutations in the ATM (AT-mutated) gene.

Symptoms include neurological abnormalities that cause unsteady posture, dilated blood vessels, infertility, radiation sensitivity, immune deficiencies and lymphoid malignancies. It appears that the diverse defects seen in ATM null mammals are manifestations of disparate signal transduction defects. The ATM protein is related to a family of proteins through a c-terminal phoshatidylinositol 3-kinase (PI3-kinase) domain. Members of the PI3-kinase family of proteins are involved in cell cycle control, DNA replication, recombination and repair. ATM also shares sequence homology with portions of the yeast RAD3 gene. The main role of ATM appears to be induction of a DNA-damage control pathway in response to genotoxic insults, such as ionizing radiation or anti-tumor medications and the programmed DNA breaks of meiosis.

Antibody Tools for the Detection of ATM Kinase

Acris Antibodies offers a range of monoclonal and polyclonal antibodies for detection of ATM by immunological techniques like immunohistochemistry / immunocytochemistry or Western blotting.

Immunohistochemical staining for ATM using NB100-104 (antibody dilution 1:500)

Fig. 1: Immunohistochemical staining for ATM using NB100-104 (antibody dilution 1:500)

Available Antibody Panel to ATM

ATM (Serine-protein kinase ATM, Ataxia telangiectasia mutated) antibody

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATM antibody

Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309] - Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 2C1 Purified Hu, Mky, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

ATM antibody

Kidney: Formalin-Fixed Paraffin Embedded (FFPE) Mouse IgG1 3E8 Purified Hu IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ATM pSer1981 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM (phospho-Ser1981) antibody (AP02410PU-N and AP024PU-S. Rabbit Aff - Purified Hu P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

ATM pSer1981 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM (phospho-Ser1981) antibody (AP02410PU-N and AP024PU-S. Rabbit Aff - Purified Hu P, WB
50 µl / €240.00
  Acris Antibodies GmbH

ATM antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

ATM (1979-1983) antibody

Immunofluorescence staining of methanol-fixed HeLa cells using ATM Antibody (AP08052PU, Red). Rabbit Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

ATM antibody

Immunofluorescence staining of methanol-fixed HeLa cells using ATM Antibody (AP08052PU, Red). Rabbit Aff - Purified Hu, Ms ICC/IF, WB
50 µl / €230.00
  Acris Antibodies GmbH

ATM pSer1981 antibody

Lane 2 shows anti-ATM pS1981 polyclonal antibody detects ATM in Hydrogen Peroxide Stimulated Human Derived MCF-7 Whole Cell Lysate. Lane 1 shows a lysate from untreated MCF-7 cell lysate. The band corresponding to ATM (370 kDa) is indicated by an arrow. After blocking, the membrane was probed with a 1:1000 dilution of the primary antibody for 1 h at room temperature followed by washes and reaction with a 1:5,000 dilution of IRDye(TM)800 conjugated Donkey anti-Rabbit IgG for 1h at room temperature. LICOR's Odyssey(R) Infrared Imaging System was used to scan and process the image. Other detection systems will yield similar results. Sheep IgG Aff - Purified Hu E, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

ATM pSer1981 antibody

Lane 2 shows anti-ATM pS1981 polyclonal antibody detects ATM in Hydrogen Peroxide Stimulated Human Derived MCF-7 Whole Cell Lysate. Lane 1 shows a lysate from untreated MCF-7 cell lysate. The band corresponding to ATM (370 kDa) is indicated by an arrow. After blocking, the membrane was probed with a 1:1000 dilution of the primary antibody for 1 h at room temperature followed by washes and reaction with a 1:5,000 dilution of IRDye(TM)800 conjugated Donkey anti-Rabbit IgG for 1h at room temperature. LICOR's Odyssey(R) Infrared Imaging System was used to scan and process the image. Other detection systems will yield similar results. Sheep IgG Aff - Purified Hu E, WB
25 µl / €190.00
  Acris Antibodies GmbH

ATM pSer1981 antibody

Dot blot analysis of anti-Phospho-ATM-pS1981 Antibody (Cat.#AP12919PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

ATM antibody

ATM Rabbit Serum Hst, Hu, Mky, Ms P, WB
0.1 ml / €520.00
  Acris Antibodies GmbH

ATM antibody

ATM Rabbit Serum Hst, Hu, Mky, Ms WB
0.1 ml / €530.00
  Acris Antibodies GmbH

ATM antibody

ATM Rabbit Biotin Hu ICC/IF, IP, P, WB
50 µl / €260.00
  Novus Biologicals Inc.

ATM antibody

ATM Rabbit DyLight488 Hu ICC/IF, IP, P, WB
50 µl / €270.00
  Novus Biologicals Inc.

ATM antibody

ATM Rabbit HRP Hu ICC/IF, IP, P, WB
50 µl / €270.00
  Novus Biologicals Inc.

ATM antibody

ATM Rabbit Aff - Purified Hu ICC/IF, IP, P, WB
50 µl / €270.00
  Novus Biologicals Inc.

ATM antibody

Western Blot: ATM Antibody (5C2) [NB100-220] - Detection of human ATM protein using ATM 5C2 monoclonal antibody in Raji whole cell extract (lane 1) and T24 syncronized cell lysate (lane 2). Mouse IgG1 5C2 Purified Hu, Mky, Ms, Rt ICC/IF, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

ATM antibody

Western Blot and  Immunoprecipitation: ATM Antibody [NB100-270] - Western blot and IP detection of human ATM using NB100-270 on WT and ATM null cells. Goat Aff - Purified Hu, Ms IP
0.1 mg / €470.00
  Novus Biologicals Inc.

ATM antibody

Western Blot: ATM Antibody [NB100-271] - Detection of Human ATR by Western blot. Samples: Whole cell lysate (20 ug) from HeLa and U20 degrees Cells separated on a 3 to 8% tris-acetate gel. Antibody: Affinity purified rabbit anti-ATR (NB100-271) used at 0.07 ug/ml. Detection: Chemiluminescence with 15 second exposure. Goat Aff - Purified Hu, Ms IP, PLA, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

ATM pSer1981 antibody

ATM Mouse IgG1 10H11.E12 Ascites Hu, Ms, Rt ICC/IF, IP, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

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