Antibody Panel to beta Amyloid - FocusOn 068

Introduction

The beta amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes ß-secretase and γ-secretase to produce beta amyloid peptides with the Aß1-42 and the Aß1-40 forms being the most prevalent.

Secreted beta amyloid peptides can bind to scavenger receptors and the receptor for advanced glycation endproducts. beta amyloid peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of beta amyloid leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease (AD). Much AD research has been focused on determining the underlying mechanism(s) of beta amyloid protein toxicity. One possible mechanism of beta amyloid protein toxicity may be through calcium-mediated neurotoxicity. Beta amyloid peptides can increase calcium influx through voltage-gated calcium channels (N- and L-type), reduce the magnesium blockade of NMDA receptors to allow increased calcium influx, and lastly, they can form a cation-selective ion channel after their incorporation into the cell membrane. Cation channels are induced by both nascent and globular beta amyloid peptides. Thus, beta amyloid peptides may elicit toxic effects prior to fibril formation. Recent evidence suggests that copper and zinc may modulate the structure of the pleimorphic beta amyloid peptides to induce either pore formation or peptide precipitation.

Antibody Tools for the Detection of beta Amyloid Peptides

Acris Antibodies offers a wide range of antibodies to Amyloid beta, which are suitable for immunohistochemistry and / or other immunological detection methods.

Various control peptides are also available.

Staining of human cerebellum using 4G8 antibody BM2568Staining of human cerebellum using 4G8 antibody BM2568

Fig. 1: Formalin fixed paraffin embedded human Alzheimer's brain stained with anti-Amylod beta (AP00627PU-N). Note staining of amyloid plaques.

Fig. 2: Formalin fixed paraffin embedded human Alzheimer’s brain stained with anti-Amyloid Precursor Protein antibody DP123 / DP123-05.

Available Antibody Panel to beta Amyloid

Anti- Amyloid beta, Amyloid Beta A4 Protein Precursor (Amyloid Precursor Protein, APP) antibody

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Amyloid beta (1-40 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2µg/ml mab bA4 (40)-5C3 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). 
Lane 1: bA4 (1-40)
Lane 2: bA4 (1-42)
Lane 3: bA4 (1-43) Mouse IgG1 5C3 Biotin Hu E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40 specific) antibody

Amyloid beta Mouse IgG1 5C3 FITC Hu ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides were applied on SDS-PAGE and transferred to a PVDF membrane. The Immunoblot was probed with 2 µg/ml mab bA4 (40)-5C3 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). 
Lane 1: bA4 (1-40), Lane 2: bA4 (1-42), Lane 3: bA4 (1-43) Mouse IgG1 5C3 Purified Hu E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-40/42) antibody

Amyloid beta Mouse IgG1 9F1 Biotin Hu E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40/42) antibody

Amyloid beta Mouse IgG1 9F1 FITC Hu ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-40/42) antibody

Amyloid beta Mouse IgG1 9F1 Purified Hu E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2µg/ml mab bA4 (42)-8G7 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec).
Lane 1: bA4(1-40)  
Lane 2: bA4 (1-42)  
Lane 3: bA4 (1-43) Mouse IgG1 8G7 Biotin Hu E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Amyloid beta Mouse IgG1 8G7 FITC Hu ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-42 specific) antibody

Figure 1. Immunoblot Analysis Amyloid beta A4 peptides: Lane 1: bA4(1-40), Lane 2: bA4 (1-42), Lane 3: bA4 (1-43) were applied on SDS-PAGE and transferred to a PVDF membrane. The Immunoblot was probed with 2 µg/ml mab bA4 (42)-8G7for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). Mouse IgG1 8G7 Purified Hu E, ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-43 specific) antibody

Amyloid beta Mouse IgG1 6G12 Biotin Hu E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (1-43 specific) antibody

Immunoblot Analysis: Amyloid beta A4 peptides (lane 1: bA4(1-40); lane 2: bA4 (1-42); lane 3: bA4 (1-43)) were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2 µg/ml AM00004PU-N for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). Mouse IgG1 6G12 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, not APP reactive) antibody

Amyloid beta Mouse IgG1 11H3 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, APP reactive) antibody

Amyloid beta Mouse IgG1 19H5 Biotin Hu E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, APP reactive) antibody

Immunoblot Analysis: Amyloid beta A4 peptides (lane 1: bA4(1-40); lane 2: bA4 (1-42); lane 3: bA4 (1-43)) were applied on SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with 2µg/ml mab bA4N-19H5 for 1h at 15-22°C and developed by ECL (exposure time: 30 sec). Mouse IgG1 19H5 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (free N-term, low APP reactive) antibody

Amyloid beta Mouse IgG1 19H11 Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Amyloid beta (1-40) antibody

Amyloid beta Rabbit IgG Aff - Purified Hu C, Dot, E, R
0.1 mg / €700.00
  Acris Antibodies GmbH

Amyloid beta (1-14) antibody

Amyloid beta Rabbit IgG Serum Hu E, P
0.1 ml / €440.00
  Acris Antibodies GmbH

Amyloid beta A4 protein / APP ( + Amyloid beta) antibody

AP15346PU Amyloid beta antibody staining of Human Alzheimer's Brain. Rabbit Purified Hu IP, P, WB
1 ml / €440.00
  Acris Antibodies GmbH

Amyloid beta A4 protein / APP antibody

Human Alzheimer’s brain stained with anti-APP antibody Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €520.00
  Acris Antibodies GmbH

Amyloid beta A4 protein / APP antibody

Immunohistochemistry: AM09000PU-N APP antibody staining of Formalin-Fixed, Paraffin-Embedded Human Brain, Cortex. Mouse IgG2b J4H9 Purified Hu, Ms E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

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