Antibody Panel to Transcription Factor AP-2 - FocusOn 064
Introduction
AP-2 is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes.
AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and c-Myc. There are three isoforms of AP-2: AP-2 alpha, beta and gamma. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. It binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. AP-2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Antibody Tools for the Detection of AP-2
OriGene Technologies offers a panel of antibodies to AP-2 (alpha, beta, gamma). These antibodies are suitable for immunological detection methods like immunohistochemistry or Western blotting / ELISA. A range of AP-2 antigens is also available.
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Fig. 1: Staining of human breast carcinoma using AP-2 antibody DM333
Fig. 2: Western blot analysis of human MCS-7 cells using AP-2 antibody SP7011P
Available Antibody Panel to AP-2
Transcription factor AP-2, AP-2 alpha, AP-2 beta, AP-2 gamma ( TFAP2A, TFAP2B, TFAP2C [ERF-1] ) antibody
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP06013PU-N | TFAP2A / AP-2 alpha antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | E, P, WB |
0.1 mg /
€350.00
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| OriGene Technologies GmbH | |||||||
 +1 additional image |
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| AP07641PU-N | TFAP2A / AP-2 alpha (3-14) antibody |
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Goat | Aff - Purified | Can, Chk, Hu, Ms, Rt | E, ICC/IF, P, WB |
50 µg /
€380.00
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| OriGene Technologies GmbH | |||||||
| AP11820PU-N | TFAP2A / AP-2 alpha (C-term) antibody |
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Rabbit | Ig | Purified | Hu | WB |
0.4 ml /
€370.00
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| OriGene Technologies GmbH | |||||||
| RA18023-100 | TFAP2A / AP-2 alpha antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | IP, P, WB |
0.1 ml /
€480.00
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| Neuromics Antibodies | |||||||
| +1 additional image |
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