Bacillus anthracis (Anthrax) - FocusOn 020

Introduction

Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. It most commonly occurs in wild and domestic mammalians (cattle, sheep etc.) in agricultural regions, including Southern and Eastern Europe. Humans can be infected with anthrax by handling products from infected animals or by inhaling anthrax spores from contaminated animal products. B. anthracis spores can survive in the soil for many years and had been produced for use as a one of the first available biological weapons.

Bacillus anthracis is a very large, Gram-positive, sporeforming rod. It was the first bacterium shown to be the cause of a disease: In 1877, Robert Koch grew the organism in pure culture, demonstrated its ability to form endospores, and produced experimental anthrax by injecting it into animals.

The vegetative bacteria excrete the tripartite exotoxin, which consists of three polypeptides: protective antigen (PA, 83 kDa), lethal factor (LF, 90 kDa) and oedema factor (OF, 89 kDa). The two components (OF and LF) of the toxin enzymatically modify substrates within the cytosol of the mammalian cells. To intoxicate mammalian cells, the third component of the toxin PA, binds to a ubiquitously expressed cellular receptor, Tumor Endothelium Marker-8 (TEM8), also known as Anthrax Toxin Receptor, ATR. Three splice variants (ATR1, ATR2 and ATR3) of TEM8/ATR have been reported.

Antibody Tools for the Detection of Bacillus anthracis

Acris Antibodies offers a full panel of antibodies for the detection of different proteins of Bacillus anthracis, including the so called “protective antigen”, the “lethal factor” and most important the “spore antigen” as well as antibodies to the human Anthrax toxin receptors (ATR). The antibodies can be used in ELISA and/ or Western blotting applications. Recombinant Anthrax proteins for control and calibration purpose are also available.



Available antibody panel to Anthrax: Bacillus anthracis antibody (B. anthracis antibody, Anthrax antibody), Anthrax Toxin Receptor antibody (ANTXR1/TEM8 antibody, ANTXR2 antibody).



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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Anthrax toxin receptor 1 / ANTXR1 antibody

Immunohistochemistry: AP14524PU-N ANTXR1 Antibody staining of Formalin-Fixed, Paraffin-Embedded Human lung carcinoma tissue. This antibody which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Anthrax toxin receptor 2 / ANTXR2 (121-133) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Eq, Hst, Hu, Ms, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Bacillus anthracis Spore Antigen antibody

Bacillus anthracis Rabbit IgG Purified E
1 mg / €460.00
  HyTest Ltd.

Bacillus anthracis Spore Antigen antibody

Bacillus anthracis Mouse IgG2a SA26 Purified E, E(capture), WB
1 mg / €480.00
  HyTest Ltd.

Bacillus anthracis Spore Antigen antibody

Bacillus anthracis Mouse IgG2a SA27 Purified E, E(detection), WB
1 mg / €480.00
  HyTest Ltd.

Bacillus anthracis lethal factor antibody

Bacillus anthracis lethal factor Mouse IgG1 BAL105 Purified E, E(detection)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis lethal factor antibody

Bacillus anthracis lethal factor Mouse IgG1 BAL106 Purified E, E(capture)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis lethal factor antibody

Bacillus anthracis lethal factor Mouse IgG2a LFA27 Purified E, E(detection)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis lethal factor antibody

Bacillus anthracis lethal factor Mouse IgG1 LFA58 Purified E, E(capture)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG2b 7821 Purified E, ICC/IF, P
0.1 mg / €340.00
  Acris Antibodies GmbH

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG2b BAP0101 Purified E
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG2b BAP0102 Purified E, E(detection)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG2b BAP0103 Purified E, E(detection)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG2b BAP0104 Purified E
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG1 BAP0105 Purified E, E(capture)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG1 BAP0106 Purified E, E(detection)
1 mg / €390.00
  HyTest Ltd.

Bacillus anthracis protective antigen antibody

Bacillus anthracis protective antigen Mouse IgG1 C3 Purified E, E(capture)
1 mg / €390.00
  HyTest Ltd.

17 Item(s)

per page
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