Antibodies to desArg9-Bradykinin and Bradykinin Receptors - FocusOn 081

Introduction

Bradykinins (BKs) are a family of short, structurally similar peptides that activate sensory fibres, contract venous smooth muscle, stimulate release of cytokines, induce connective tissue proliferation and mediate endothelium-dependent vasodilation. BK antagonists are of potential use in the treatment of inflammation, asthma, mild pain and endotoxic shock.

BK receptors are widespread in peripheral tissues, and at least 3 different receptor subtypes have been proposed. Of these, B2 is the predominant subtype, mediating slow contraction of various smooth muscles (including veins, intestine, uterus, trachea and lung), inducing endothelium-dependent relaxation of arteries and arterioles, and stimulating natriuresis/diuresis in kidney. Bradykinin B1 receptor is generally only minimally expressed under normal physiological conditions, but the expression is induced rapidly under pathologic conditions such as ischemia, atheromatous disease, or exposure to inflammatory cytokines. Expression has been reported in brain, colon, kidney, lung, nasal mucosa, pancreas, prostate, skin, spinal cord, and vessel. Des-Arg9-bradykinin, the active metabolite of bradykinin is the selective bradykinin B1-receptor agonist.

Antibody Panel to desArg9-Bradykinin and Bradykinin Receptors

Acris Antibodies offers a range of polyclonal antibodies to desArg9-Bradykinin, Bradykinin B1 and Bradykinin B2 Receptor .The antibodies can be used for immunohistochemistry on paraffin embedded sections and other applications, respectively . All antibodies are reactive on human and rodent tissues. Receptor-antibodies were made to cytoplasmic domains to achieve maximum specifity .

BDKRB1BDKRB2
Fig. 1: <span>Immunohistochemical staining of Nasal mucosa section using anti-BDKRB1 antibody SP4076P (Formalin-Fixed Paraffin Embedded).</span>
Fig. 1: Immunohistochemical staining of Nasal mucosa section using anti-BDKRB1 antibody SP4076P (Formalin-Fixed Paraffin Embedded).
Fig. 2: <span>Artery, atherosclerosis, tunica media: Formalin-Fixed Paraffin-Embedded (FFPE)</span>
Fig. 2: Artery, atherosclerosis, tunica media: Formalin-Fixed Paraffin-Embedded (FFPE). Cat.-No. 
Fig. 3: <span>Immunofluorescent detection of Bradykinin R2 in Rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence).</span>
Fig. 3: Immunofluorescent detection of Bradykinin R2 in Rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence). Cat.-No. AP32712SU-N

Antibody Panel to desArg9-Bradykinin and Bradykinin Receptors

desArg9-Bradykinin , Bradykinin B1 receptor, Bradykinin B2 receptor, antibody.

Literature

Gardes J, Michineau S, Pizard A, Alhenc-Gelas F, Rajerison RM. Aspirin inhibits human bradykinin B(2) receptor ligand binding function. Biochem Pharmacol. 2008 Feb 12 [Epub ahead of print]

Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Psquero JB, Bader M, Avellae MC, Campos MM, Calixto JB: Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein:… Circ. Res. 2004 May 28; 94(10): 1375-82.

Zhang Y, Adner M, Cardell LO. Up-regulation of bradykinin receptors ina murine in-vitro model of chronic airway inflammation. Eur J Pharmacol. 2004 Apr. 5; 489(1-2): 117-26.

Pinheiro RM, Campos MM, Calixto JB. Analysis of the mechanisms involved in the inflammatory response induced by des-Arg9-bradykinin in the rat pleural cavity. Inflamm Res. 2001 Nov; 50(11): 570-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BDKRB1 (Center) antibody

Western blot (WB) analysis of Bradykinin B1 R antibody (Cat.-No.: AP01308PU-N) in extracts from K562 cells. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BDKRB1 (Center) antibody

Western blot analysis of BDKRB1 Antibody (Center) (AP17901PU-N) in HepG2 cell line lysates (35ug/lane). BDKRB1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BDKRB1 (C-term) antibody

Immunohistochemical staining of Human Vascular Smooth Muscle Ssections using anti-BDKRB1 antibody SP4076P (Formalin-Fixed Paraffin Embedded). Rabbit Aff - Purified Bear, Bov, Eq, Hu, Mky, Por, Prim P
50 µg / €470.00
  Acris Antibodies GmbH

BDKRB2 antibody

Immunofluorescent detection of Bradykinin R2 in Rat brain using Cy3 conjugated anti-rabbit secondary antibodies (red fluorescence). Rabbit Serum Ms, Rt C, ICC/IF
0.1 ml / €270.00
  Acris Antibodies GmbH

BDKRB2 antibody

Human Jurkat; WB Suggested Anti-BDKRB2 Antibody Titration: 5.0ug/ml. Positive Control: Jurkat cell lysate; BDKRB2 antibody - N-terminal region (AP32713PU-N) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
0.1 mg / €310.00
  Acris Antibodies GmbH

Bradykinin (desArg9) antibody

Bradykinin Rabbit Purified Hu C, WB
50 µl / €490.00
  Acris Antibodies GmbH

Bradykinin antibody

Bradykinin Rabbit IgG Purified Br, Hu E
1 ml / €390.00
  Acris Antibodies GmbH

7 Item(s)

per page
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