Glucose Transporter (Glut 1-13) Antibodies - FocusOn 016

Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters (Glut or SLC2A family / solute carrier family 2). Molecular cloning of these glucose transporters has identified a family of closely related genes. Individual members of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. There is a large extracellular domain between TM1-TM2 and a cytoplasmic domain between TM6-TM7. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting.

Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics.

GLUT1 mediates glucose transport into red cells, and throughout the blood brain barrier. It is ubiquitously expressed and transports glucose in most cells.

GLUT2 provides glucose to the liver and pancreatic cells.

GLUT3 is the main transporter in neurons.

GLUT4 is primarily expressed in muscle and adipose tissue and regulated by insulin.

GLUT5 transports fructose in intestine and testis.

GLUT6 name was previously assigned to a pseudoegene. Now Glut-9 has been renamed as Glut-6 (human 507 aa; ~45% identity with Glut-8). It is highly expressed in brain, spleen, and leukocytes.

GLUT7, expressed in liver and other gluconeogenic tissues, mediates glucose flux across endoplasmic reticulum membrane.

Most recently, GLUT8 (mouse/rat/human 477 aa, ~30% identity with Glut-1) has been cloned and characterized. High levels are found in adult testis and placenta.

Human GLUT9 (540 aa; chromosome 4p15.3-p16) is approx 45% identical with Glut-5, and 38% with Glut-1. It is expressed in kidney, followed by liver. Glut-9 is also detected in placenta, lung, blood leukocytes, heart, and skeletal muscle.

Human GLUT10 (541 aa, chromosome 20q13.1; ~30-35% homology with Glut-3 and Glut-8) has been identified as a candidate gene for NIDDM susceptibility. It is widely expressed with highest levels in liver and pancreas.

GLUT11 (496 aa, chromosome 22q11.2; ~41% identity with Glut-5) is expressed in heart and skeletal muscle. Recently, a few novel members of Glut family have been identified.

GLUT12 (human 617 aa; 29% identity with Glut-4 and 40% with Glut-10). It is expressed in skeletal muscle, adipose tissue, and small intestine.

GLUT13 or H+ myo-inositol transporter (HMIT, rat 618 aa; human 629 aa; ~36% identity with Glut-8). It is predominantly expressed in brain.

Antibody Tools for the Detection of Glucose Transporter

Acris Antibodies offers a panel of antibodies to Glut-1 to Glut-13 which were produced using antigenic sequences unique to each protein. These antibodies do not crossreact with each other and can be used to study specific Glut in mouse, rat, and human tissues.

Fig. 1: AP07454PU-N GLUT10 antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney.
Fig. 1: AP07454PU-NGLUT10 antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney.
Fig. 2: BP508 GLUT4 antibody staining of Paraffin Embedded Human Heart, demonstrating labelling of cardiac myocytes.
Fig. 2: BP508 GLUT4 antibody staining of Paraffin Embedded Human Heart, demonstrating labelling of cardiac myocytes.
Fig. 3: Human placenta stained with anti-GLUT-3 antibody.
Fig. 3: Human placenta stained with anti-GLUT-3 antibody. Cat.-No. AP15583PU-N
Fig. 4: Human lung carcinoma stained with anti-GLUT1 antibody.
Fig. 4: Human lung carcinoma stained with anti-GLUT1 antibody. Cat.-No. AM32430PU-N

Available antibody panel to Glut 1-13

Glucose Transporter 1 antibody (Glut1 antibody / Glut-1 antibody), Glucose Transporter 2 (Glut2 / Glut-2 ), Glucose Transporter 3 (Glut3 / Glut-3 ), Glucose Transporter 4 (Glut4 / Glut-4 ), Glucose Transporter 5 (Glut5 / Glut-5 ), Glucose Transporter 6 (Glut6 / Glut-6 ), Glucose Transporter 7 (Glut7 / Glut-7 ), Glucose Transporter 8 (Glut8 / Glut-8 ), Glucose Transporter 9 (Glut9 / Glut-9 ), Glucose Transporter 10 (Glut10 / Glut-10 ), Glucose Transporter 11 (Glut11 / Glut-11 ), Glucose Transporter 12 (Glut12 / Glut-12 ), Glucose Transporter 13 (Glut13 / Glut-13 )

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GLUT1 / SLC2A1 (C-term) antibody

Human Esophagous stained with anti-GLUT1 Antibody Cat.-No AM11138PU (Clone SPM498) Mouse SPM498 Purified Hu, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

GLUT1 / SLC2A1 (C-term) antibody

Human Esophagous stained with anti-GLUT1 Antibody Cat.-No AM11138PU (Clone SPM498) Mouse SPM498 Purified Hu, Rt P
0.1 ml / €200.00
  Acris Antibodies GmbH

GLUT1 / SLC2A1 (C-term) antibody


Human lung carcinoma stained with anti-GLUT1 antibody
Rabbit IgG SP168 Purified Hu P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

GLUT1 / SLC2A1 (C-term) antibody


Human lung carcinoma stained with anti-GLUT1 antibody
Rabbit IgG SP168 Purified Hu P, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

GLUT1 / SLC2A1 antibody

Human esophagous carcinoma stained with Anti-GLUT-1 antibody Rabbit Purified Hu, Rt ICC/IF, P
1 ml / €520.00
  Acris Antibodies GmbH

GLUT1 / SLC2A1 (C-term) antibody

Human esophagous carcinoma stained with Anti-GLUT-1 antibody Rabbit Purified Hu, Rt ICC/IF, P
0.1 ml / €190.00
  Acris Antibodies GmbH

GLUT1 / SLC2A1 antibody

Immunohistochemistry (IHC) analysis of GLUT1 antibody (Cat.-No.: AP06144PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GLUT2 / SLC2A2 antibody

AM08399PU-N, at 10 µg/ml, staining Glucose Transporter GLUT2 in formalin-fixed, paraffin-embedded human Liver tissue by Immunohistochemistry. Mouse IgG2a 5D1 Purified Hu F, ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

GLUT2 / SLC2A2 (C-term) antibody

GLUT2 / SLC2A2 Rabbit Serum Rt C, WB
0.1 ml / €330.00
  Acris Antibodies GmbH

GLUT2 / SLC2A2 (N-term) antibody

Western blot analysis of SLC2A2 Antibody (N-term) (AP11502PU-N) in HL60 cell line lysates (35 µg/lane). SLC2A2 (arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GLUT3 / SLC2A3 antibody

Human placenta stained with anti-GLUT-3 antibody Rabbit Purified Hu E, P, WB
1 ml / €440.00
  Acris Antibodies GmbH

GLUT3 / SLC2A3 antibody

Human placenta stained with anti-GLUT-3 antibody Rabbit Purified Hu E, P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

GLUT3 / SLC2A3 antibody

Immunohistochemistry (IHC) analysis of GLUT3 antibody (Cat.-No. AP06145PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GLUT4 / SLC2A4 (C-term) antibody

Figure 1. BP508 GLUT4 antibody staining of Paraffin Embedded Human Heart, demonstrating labelling of cardiac myocytes. Rabbit Purified Hu, Mky, Ms, Rt C, IP, P, WB
0.1 ml / €470.00
  Acris Antibodies GmbH

GLUT4 / SLC2A4 (C-term) antibody

AP07533PU-N SLC2A4 antibody staining of Formalin-Fixed Paraffin-Embedded Human Heart, Cardiac Myocytes at 10-20 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Mky, Ms, Rt C, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

GLUT5 / SLC2A5 (C-term) antibody

GLUT5 / SLC2A5 Rabbit Aff - Purified Ms, Rt Dot, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GLUT5 / SLC2A5 (482-493) antibody

Small intestine, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Can, Elephant, Hu, Mky, Prim, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

GLUT5 / SLC2A5 antibody

GLUT5 / SLC2A5 Rabbit Purified Hu P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

GLUT7 / SLC2A7 (C-term) antibody

GLUT7 / SLC2A7 Rabbit Aff - Purified Ms, Rt Dot, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GLUT10 / SLC2A10 (367-385) antibody

Figure 1. AP07454PU-N GLUT10 antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney. Rabbit IgG Aff - Purified Hu, Mky, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

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