Antibodies to ICOS (CD278) and ICOS Ligand (CD275) - FocusOn 014

ICOS (CD278, AILIM, CRP-1, Inducible T-cell costimulator) enhances T-cell responses to foreign antigens, participating in the stimulation of proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and antibody secretion by B-cells. ICOS is critical in fostering T/B-cells interaction and for normal antibody responses to T-cell dependent antigens. Other immune response roles for ICOS include superinduction of interleukin-10 (IL-10) synthesis, thwarting apoptosis of pre-activated T-cells and assistance in CD40-mediated class switching of immunoglobin isotypes.

ICOS Ligand (CD275, ICOSLG, inducible T cell co stimulator ligand) is a member of the B7 family and the immunoglobulin superfamily. Human ICOS ligand is expressed by activated monocytes/macrophages and dendritic cells. It is the ligand for the T-cell-specific cell surface receptor ICOS (CD278, AILIM, CRP-1, Inducible T-cell costimulator), which is expressed by activated T cells. This interaction plays an important role in the T cell costimulation pathway. ICOS Ligand acts as a costimulatory signal for T-cell proliferation and cytokine secretion, and also induces B-cell proliferation and differentiation into plasma cells. ICOS Ligand may facilitate local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function

AM08360PU-N CD275/ICOS Ligand antibody staining of Formalin-Fixed, Paraffin-Embedded Human Brain Cortex.
Fig.1: Cat.-No. AM08360PU-N CD275/ICOS Ligand antibody staining of Formalin-Fixed, Paraffin-Embedded Human Brain Cortex.
AP07922PU-N CD278/ICOS antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen tissue.
Fig.2: Cat.-No. AP07922PU-N CD278/ICOS antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen tissue.

Antibody Tools for the Detection of ICOS and ICOSL

Acris Antibodies offers a panel of monoclonal antibodies to ICOS and ICOS Ligand (B7RP-1) for use in flow cytometry or other immunological applications.

Available antibody panel to ICOS and ICOS Ligand:ICOS antibody, CD278 antibody, ICOS Ligand antibody, (ICOSL antibody / ICOS-L antibody), B7RP-1 antibody (B7RP1 antibody), CD275 antibody

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD275 / ICOS Ligand antibody

Fig.2: SDS-PAGE analysis of purified GM-13C1 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 µg of purified GM-13C1 antibody. Proteins were separated by SDS-PAGE and stained with RAPID StainTM Reagent. Mouse IgG1 GM13C1 Purified Hu E, F
0.1 mg / €330.00
  Acris Antibodies GmbH

CD275 / ICOS Ligand antibody

Figure 1. Staining of Human peripheral blood monocytes with Mouse anti Human CD275 antibody FITC conjugated (AM05615FC-N). Mouse IgG1 MIH11 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD275 / ICOS Ligand antibody

Figure 1. Staining of Human peripheral blood monocytes with Mouse anti Human CD275 antibody (AM05615PU-N) Mouse IgG1 MIH11 Purified Hu C, F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD275 / ICOS Ligand (C-term) antibody

Western blot analysis of CD275 / ICOS Ligand (C-term) Antibody Cat.-No AP52143PU-N in HL-60 cell line lysates (35ug/lane). This demonstrates the ICOSLG antibody detected the ICOSLG protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Human reactive lymph node stained with anti-CD278 antibody AM20270PU Rabbit IgG SP98 Purified Hu, Rt P
0.5 ml / €510.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Human reactive lymph node stained with anti-CD278 antibody AM20270PU Rabbit IgG SP98 Purified Hu, Rt P
0.1 ml / €290.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

AP23811PU CD278 antibody staining of Human Tonsil. Rabbit IgG Aff - Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD278 / ICOS antibody

AP23811PU CD278 antibody staining of Human Tonsil. Rabbit IgG Aff - Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

CD278 / ICOS (171-186) antibody

Figure 1. AP07922PU-N CD278/ICOS antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

CD278 / ICOS (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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