Properties for Human DKK-1 ELISA Kit
|Product Category||ELISA Kits|
|Shipping to||Not USA/Canada|
|PDF datasheet||View Datasheet|
|Manufacturer certificates||ISO 9001|
|Add. information||Sensitivity < 10 pg/ml|
|Application||Sandwich ELISA kit of Quantitative Detection for Human DKK-1
This kit is used for quantitative detection of human DKK-1 in cell culture supernates, serum and plasma(heparin, EDTA).
There is no detectable cross-reactivity with other relevant proteins.
|Background||Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene, which was mapped to chromosome 10q11.2. This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow, plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.|
|General Readings||"Entrez Gene: DKK1 dickkopf homolog 1 (Xenopus laevis)"
2. Roessler, E., Du, Y., Glinka, A., Dutra, A., Niehrs, C., Muenke, M. The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. Cytogenet. Cell Genet. 89: 220-224, 2000.
|Storage||Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)|