BB-EK0779 Human Interleukin 7 ELISA Kit

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Properties for Human Interleukin 7 ELISA Kit

Product Category ELISA Kits
Quantity 96 Tests
Reactivity Hu
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Boster Immunoleader
Manufacturer certificates ISO 9001

Datasheet Extract

Swiss Prot Num:
Add. information Sensitivity < 1 pg/ml
Application Sandwich ELISA kit of Quantitative Detection for Human Interleukin 7
This kit is used for quantitative detection of human Interleukin 7 in cell culture supernates, serum and plasma(EDTA).
There is no detectable cross-reactivity with other relevant proteins.
Background IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes,1 dendritic cells,2 hepatocytes,3 neurons, and endothelial cells4 . Interleukin 7 (IL7) is a protein5 that in humans is encoded by the IL7 gene.6,7,8Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.9 IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development.10
General Readings
  1. Heufler C, Topar G, Grasseger A, Stanzl U, Koch F, Romani N, et al. Interleukin 7 is produced by murine and human keratinocytes. J Exp Med. 1993 Sep 1;178(3):1109-14. PubMed PMID: 8350050. (Free PMC Article available)
  2. Kröncke R, Loppnow H, Flad HD, Gerdes J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol. 1996 Oct;26(10):2541-4. PubMed PMID: 8898972.
  3. Sawa Y, Arima Y, Ogura H, Kitabayashi C, Jiang JJ, Fukushima T, et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity. 2009 Mar 20;30(3):447-57. doi: 10.1016/j.immuni.2009.01.007. Epub 2009 Mar 12. PubMed PMID: 19285437.
  4. Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest. 1995 Jun;95(6):2945-53. PubMed PMID: 7769137. (Free PMC Article available)
  5. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988 Jun 9;333(6173):571-3. PubMed PMID: 3259677.
  6. Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, et al. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci U S A. 1989 Jan;86(1):302-6. PubMed PMID: 2643102. (Free PMC Article available)
  7. Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, et al. The gene for human interleukin 7 (IL7) is at 8q12-13. Hum Genet. 1989 Jul;82(4):371-2. PubMed PMID: 2786840.
  8. Lupton SD, Gimpel S, Jerzy R, Brunton LL, Hjerrild KA, Cosman D, et al. Characterization of the human and murine IL-7 genes. J Immunol. 1990 May 1;144(9):3592-601. PubMed PMID: 2329282.
  9. "Entrez Gene: IL7 interleukin 7".
  10. Muegge K, Vila MP, Durum SK. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. Science. 1993 Jul 2;261(5117):93-5. PubMed PMID: 7686307.
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Range 15.6-1000 pg/ml
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