BB-EK0921 Human TNFSF13/APRIL ELISA Kit

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96 Tests / €420.00
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BB-EK0921

Properties for Human TNFSF13/APRIL ELISA Kit

Product Category ELISA Kits
Quantity 96 Tests
Reactivity Hu
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Boster Immunoleader
Manufacturer certificates ISO 9001

Datasheet Extract

Immunogen
Swiss Prot Num:
Q2QBA2
Add. information Sensitivity < 10 pg/ml
Application Sandwich ELISA kit of Quantitative Detection for Human TNFSF13/APRIL
This kit is used for quantitative detection of human TNFSF13 in cell culture supernates, serum and plasma(heparin, EDTA).
There is no detectable cross-reactivity with other relevant proteins.
Background Tumor necrosis factor ligand superfamily member 13 (TNFSF13) also known as a proliferation-inducing ligand(APRIL) is a protein that in humans is encoded by the TNFSF13 gene. TNFSF13 has also been designated CD256(cluster of differentiation 256). The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in April showed a reduced ability to support plasma cell survival In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such asTNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The TNFSF13 gene lies 878 bp downstream of the TNFSF12 gene on chromosome 17p13.1.
General Readings
  1. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998 Sep 21;188(6):1185-90. PubMed PMID: 9743536. (Free PMC Article available, 4 images available)
  2. "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13".
  3. Pradet-Balade B, Medema JP, López-Fraga M, Lozano JC, Kolfschoten GM, Picard A, et al. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. EMBO J. 2002 Nov 1;21(21):5711-20. PubMed PMID: 12411489. (Free PMC Article available, 8 images available)
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Range 156-10,000 pg/ml
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