BB-EK0723 Mouse CXCL1 ELISA Kit

Search for all "Mouse CXCL1 ELISA Kit"

96 Tests / €490.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.


Properties for Mouse CXCL1 ELISA Kit

Product Category ELISA Kits
Quantity 96 Tests
Reactivity Ms
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Boster Immunoleader
Manufacturer certificates ISO 9001

Datasheet Extract

Swiss Prot Num:
Add. information Sensitivity < 1 pg/ml
Application Sandwich ELISA kit of Quantitative Detection for Mouse CXCL1
This kit is used for quantitative detection of mouse CXCL1 in cell culture supernates and serum.
There is no detectable cross-reactivity with other relevant proteins.
Background Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. The standard product used in this kit is recombinant mouse CXCL1, consisting of 77 amino acids with the molecular mass of 8KDa.
General Readings
  1. Richmond A, Thomas HG. Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution. J Cell Biochem. 1988 Feb;36(2):185-98. PubMed PMID: 3356754.
  2. Becker S, Quay J, Koren HS, Haskill JS (March 1994). "Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages". Am. J. Physiol. 266 (3 Pt 1): L278–86.
  3. Schumacher C, Clark-Lewis I, Baggiolini M, Moser B. High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10542-6. PubMed PMID: 1438244. (Free PMC Article available)
  4. Tsai HH, Frost E, To V, Robinson S, Ffrench-Constant C, Geertman R, et al. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Cell. 2002 Aug 9;110(3):373-83. PubMed PMID: 12176324.
  5. Omari KM, Lutz SE, Santambrogio L, Lira SA, Raine CS. Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol. 2009 Jan;174(1):164-76. doi: 10.2353/ajpath.2009.080350. Epub 2008 Dec 18. PubMed PMID: 19095949. (Free PMC Article available, 8 images available)
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Range 15.6-1000 pg/ml
  • LinkedIn