BB-EK0363 Rat GDNF ELISA Kit

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96 Tests / €470.00
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BB-EK0363

Properties for Rat GDNF ELISA Kit

Product Category ELISA Kits
Quantity 96 Tests
Reactivity Rt
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Boster Immunoleader
Manufacturer certificates ISO 9001

Datasheet Extract

Immunogen
Swiss Prot Num:
A7UGJ1
Add. information Sensitivity < 4 pg/ml
Application Sandwich ELISA kit of Quantitative Detection for Rat GDNF
This kit is used for quantitative detection of rat GDNF in cell culture supernates, serum and plasma(heparin, EDTA).
There is no detectable cross-reactivity with other relevant proteins.
Background Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily.1 GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures.2 GDNF, in addition to its potential role in the differentiation and survival of central nervous system neurons, has profound effects on kidney organogenesis and the development of the peripheral nervous system.3 GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.1 GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3 ability to promote dopamine uptake in midbrain cultures.2 The standard product used in this kit is recombinant rat GDNF, which is a dimmer composed of two chains with 134 amino acids.
General Readings
  1. Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 1993 May 21;260(5111):1130-2. PubMed PMID: 8493557.
  2. Bermingham N, Hillermann R, Gilmour F, Martin JE, Fisher EM. Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5. Hum Genet. 1995 Dec;96(6):671-3. PubMed PMID: 8522325.
  3. Durbec P, Marcos-Gutierrez CV, Kilkenny C, Grigoriou M, Wartiowaara K, Suvanto P, et al. GDNF signalling through the Ret receptor tyrosine kinase. Nature. 1996 Jun 27;381(6585):789-93. PubMed PMID: 8657282.
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Range 31.2-2000 pg/ml
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