BB-EK0393 Rat IL-1 beta ELISA Kit

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96 Tests / €470.00
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BB-EK0393

Properties for Rat IL-1 beta ELISA Kit

Product Category ELISA Kits
Quantity 96 Tests
Reactivity Rt
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Boster Immunoleader
Manufacturer certificates ISO 9001

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5BKB0
Add. information Sensitivity < 1 pg/ml
Application Sandwich ELISA kit of Quantitative Detection for Rat IL-1 beta
This kit is used for quantitative detection of rat IL-1 beta in cell culture supernates, serum and plasma(heparin, EDTA).
There is no detectable cross-reactivity with other relevant proteins.
Background The Interleukin 1 family is a group of 11 beta trefoil cytokines.1 Interleukin-1, produced mainly by blood monocytes, mediates the panoply of host reactions collectively known as acute phase response .2 Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption, and has been implicated in the pathogenesis of high bone turnover and osteoporosis.3 IL-1beta belongs to proinflammatory cytokines, promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular cell adhesion molecule-1 (VCAM-1) on hepatic sinusoidal endothelium (HSE).4
General Readings
  1. Vincent T. DeVita; Theodore S. Lawrence; Steven A. Rosenberg; Robert A. Weinberg, Ronald A. DePinho (1 April 2008). DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology. Lippincott Williams & Wilkins. pp. 506–. ISBN 9780781772075. http://books.google.com/books?id=NF90HzUFPjgC&pg=PA506. Retrieved 3 December 2010.
  2. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 1985 Jun 20-26;315(6021):641-7. PubMed PMID: 2989698.
  3. Langdahl BL, Løkke E, Carstens M, Stenkjaer LL, Eriksen EF. Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner Res. 2000 Mar;15(3):402-14. PubMed PMID: 10750554.
  4. Vidal-Vanaclocha F, Fantuzzi G, Mendoza L, Fuentes AM, Anasagasti MJ, Martín J, et al. IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):734-9. PubMed PMID: 10639148. (Free PMC Article available, 5 images available)
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Range 31.2-2000 pg/ml
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