NB110-81558 17-AAG

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1 mg / €360.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.


Properties for 17-AAG

Product Category Natural Compounds
Quantity 1 mg
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Application Synthetic 17-AAG Soluble in DMSO (> 20mg/mL) or mehtanol (10mg/mL) Purple solid
Background Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).
General Readings
  1. Neckers L. (2002) Trends Mol Med. 84: S55-61.
  2. Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003 Sep 25;425(6956):407-10. PubMed PMID: 14508491.
  3. Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res. 2003 May 1;63(9):2139-44. PubMed PMID: 12727831.
  4. Vasilevskaya IA, Rakitina TV, O'Dwyer PJ. Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines. Mol Pharmacol. 2004 Jan;65(1):235-43. PubMed PMID: 14722256.
  5. Jia W, Yu C, Rahmani M, Krystal G, Sausville EA, Dent P, et al. Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Blood. 2003 Sep 1;102(5):1824-32. Epub 2003 May 8. PubMed PMID: 12738674.
Storage Store at -20°C. Avoid freeze-thaw cycles.
17-AAG Compound

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