NB110-81559 Geldanamycin

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1 mg / €290.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

NB110-81559

Properties for Geldanamycin

Product Category Natural Compounds
Quantity 1 mg
Synonyms Hsp90 inhibitor
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Add. information Geldanamycin produced by fermentation.
>95% pure
Slightly soluble in methanol, chloroform or DMSO (10mg/mL); insoluble in water.
Yellow solid
Application , Geldanamycin produced by fermentation. >95% pure Slightly soluble in methanol, chloroform or DMSO (10mg/mL); insoluble in water. Yellow solid
Background Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1
General Readings 1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324.
2. Neckers L. (2002) Trends Mol. Med. 8: S55.
3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
4. Chavany C., et al. 1996) Amer. Society Biochem Mol Bio. 9: 4974-4977.
5. Villa R., et al. (2003) Carcinogenesis. 24(5): 851-9.
6. Yamaki H., Iguchi-Ariga S.M., and Ariga H. (1989) J
Antibiot (Tokyo) 42(4): 604-10.
Storage Store at -20C. Avoid freeze-thaw cycles.
Specificity
Specificity:
Geldanamycin Compound
Species:
Not tested in other species.

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