NB110-81566 Radicicol

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1 mg / €310.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

NB110-81566

Properties for Radicicol

Product Category Natural Compounds
Quantity 1 mg
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Add. information Synthetic Radicicol, produced by fermentation. Soluble in DMSO. White to light yellow powder.
Application , Synthetic Radicicol, produced by fermentation. Soluble in DMSO. White to light yellow powder.
Background Radicicol inhibits src (IC50=0.27μM) and src-like kinases, leading to hypophosphorylation of retinoblastoma tumor suppressor protein. It causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. It also displays anti-angiogenic activity, and binds to and inhibits Hsp 90 molecular chaperone. It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.f
General Readings
  1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.
  2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.
  3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118:221.
  4. Soga S., et al. (1998) J.Biol.Chem. 273:822.
  5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241:221.
  6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.
Storage Store at -20C. Avoid freeze-thaw cycles.
Specificity
Specificity:
Radicicol Compound
Species:
Not tested in other species.

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