Product Description for AKT1
Properties for AKT1
|Product Category||Proteins & Growth Factors|
|Synonyms||AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, RAC-alpha serine/threonine-protein kinase|
|Molecular weight||58.1 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 85 % by SDS - PAGE|
|Background||AKT1 serine-threonine protein kinase is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|General Readings||Dobashi Y., et al. (2014) Hum. Pathol. 45 (1), 127-136Liu K, et al. (2013) Mol. Cell. Biol. 33 (23), 4685-4700|
|Storage||Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.