SA6000 Alpha-Synuclein / SNCA (A30P Mutant)

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0.1 mg / €230.00
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Alpha-Synuclein / SNCA

SA6000

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Product Description for Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Properties for Alpha-Synuclein / SNCA

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Presentation Purified
Molecular weight 14.486 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P37840
Purity > 95 % by SDS-PAGE
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Concentration 1.0 mg/ml
General Readings
  1. Kruger R, et al. (1998) Nat Genet. 18, 106-108.
  2. Park, S. M. et. al. (2002) Blood. 100(7), 2506-2514.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
A Parkinson's disease-related point mutant (A30P) of alpha-synuclein. A30P mutant of alpha-synuclein was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
AA Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Molecular weight:
(Real molecular size on SDS-PAGE will be shift up)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
Purity:
>95% by SDS-PAGE
State:
Liquid protein
Purified
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