SA6008 Alpha-Synuclein / SNCA (1-60)

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0.1 mg / €230.00
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Alpha-Synuclein / SNCA


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  • SA6008

Product Description for Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Properties for Alpha-Synuclein / SNCA

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Presentation Purified
Molecular weight 6.149 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Swiss Prot Num:
Purity > 95 % by SDS-PAGE
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Concentration 1.0 mg/ml
General Readings
  1. Ueda et al., (1993) Proc. Natl. Acad. Sci. 90, 11282-11286.
  2. Jakes et al., (1994) FEBS Letters 345, 27-32.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
A deletion mutant of alpha-synuclein (amino acids 1-60), which contains the N-terminal amphipathic domain.Syn1-60 was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by using conventional column chromatography techniques.
AA Sequence:
Molecular weight:
(60 amino acids)
Buffer System:
20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
>95% by SDS-PAGE
Liquid protein
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