AR10368PU-S Bivalirudin

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Product Description for Bivalirudin

Presentation: Purified

Properties for Bivalirudin

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Source Synthetic
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Background Bivalirudin directly inhibits thrombin by specifically binding as well to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Bivalirudin is a specific and reversible direct thrombin inhibitor.
Thrombin, which is a serine protease, plays a central role in the thrombotic process; it cleaves fibrinogen into fibrin monomers and activates Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked structure which stabilizes the thrombus. Thrombin also activates Factors V and VIII, which promotes further thrombin generation, activates platelets, stimulating aggregation and granule release. 
Concentration 1 mg/ml
Storage Lyophilized Bivalirudin although stable at RT for 3 weeks, should be stored desiccated below -18°C.
Upon reconstitution Bivalirudin should be stored at 2-8°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Source Synthetic
The active of Bivalirudin substance is a Synthetic 20 amino acid peptide.
AA Sequence:
Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly- Asp-Gly-Asp-Phe-Glu-Glu-Ile- Pro-Glu-Glu-Tyr-Leu.
Molecular weight:
2180 dalton
Buffer System:
Lyophilized with 0.5mg Manntiol and Sodium Hydroxide 50µg, pH-5.5
> 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Sterile Filtered White lyophilized (freeze-dried) powder.
It is recommended to restore the lyophilized Bivalirudin in sterile 18MΩ-cm-1 H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
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