AR10741PU-L Cyclosporine-A

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Product Description for Cyclosporine-A

Presentation: Purified

Properties for Cyclosporine-A

Product Category Proteins & Growth Factors
Quantity 100 g
Presentation Purified
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98.0% as determined by both RP-HPLC and Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}

Cyclosporine A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation.
Cyclosporine acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation.
Cyclosporine A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents.
Nevertheless, Cyclosporine A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism.

Storage Prior to reconstitution store at 2-8°C for one month or desiccated below -18°C.
Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing. 
Shelf life: one year from despatch.
Source Beauveria nlyea
Cyclosporine is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a Molecular Weight of 1202.64. It is produced as a metabolite by the fungus species Beauveria nlyea.
Chemically, Cyclosporine is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D- alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L-α-amino-butyryl- N-methylglycyl-N- methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).
Molecular formula: C62H111N11O12
Buffer System:
Lyophilized from a concentrated (1 mg/ml) solution with no additives
> 98.0% as determined by both RP-HPLC and Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}
Sterile Filtered White lyophilized (freeze-dried) powder
Restore in sterile 18MΩ-cm-1 H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions
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