AR09017PU-L Desert hedgehog / DHH (23-198, His-tag)

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0.5 mg / €750.00
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Quick Overview

Desert hedgehog / DHH

Product Description for Desert hedgehog / DHH

Desert hedgehog / DHH.
Presentation: Purified

Properties for Desert hedgehog / DHH

Product Category Proteins & Growth Factors
Target Category
Quantity 0.5 mg
Synonyms HHG-3
Presentation Purified
Molecular weight 22 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O43323
Purity > 95 % > 95% by SDS PAGE
Add. information NCBI Accession No.: NP_066382
Background DHH belongs to the hedgehog family. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N- terminal domain is the active species in both local and long-range signaling, whereas the C-terminal domain has no signaling activity. This protein is produced by Sertoli cells and may be involved in both male gonadal differentiation and perineurial development. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy.
Concentration 1.0 mg/ml
General Readings
  1. Chen YJ, Sims-Mourtada J, Izzo J, Chao KS. Targeting the hedgehog pathway to mitigate treatment resistance. Cell Cycle. 2007 Aug 1;6(15):1826-30. Epub 2007 Jun 5. PubMed PMID: 17671418.
  2. van den Brink GR. Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev. 2007 Oct;87(4):1343-75. PubMed PMID: 17928586.
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Description
Description:
Recombinant DHH protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MCGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG
Molecular weight:
22.0 kDa (197 aa) confirmed by MALDI-TOF
Format
Buffer System:
20mM MES pH 5.5 containing 0.5mM DTT, 20% Glycerol
Purity:
>95% > 95% by SDS PAGE
State:
Liquid purified protein
Purified
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