AR09155PU-N Dysbindin (1-270, His-tag)

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0.1 mg / €370.00
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Dysbindin

AR09155PU-N

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  • AR09155PU-N

Product Description for Dysbindin

Dysbindin.
Presentation: Purified

Properties for Dysbindin

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms DTNBP1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein homolog, Hps7-like protein, My031
Presentation Purified
Molecular weight 34.6 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q96EV8
Purity > 95 % by SDS - PAGE
Background DTNBP1 (Dysbindin) is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes.
Concentration 0.5 mg/ml (determined by Bradford assay)
General Readings Li W., et al. (2003). Nat Genet. 35(1):84-9.
Chen XW., et al. (2008). J Cell Biol. 181(5):791-801.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
AA Sequence:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMLS AHWEKKKTSL VELQEQLQQL PALIADLESM TANLTHLEAS FEEVENNLLH LEDLCGQCEL ERCKHMQSQQ LENYKKNKRK ELETFKAELD AEHAQKVLEM EHTQQMKLKE RQKFFEEAFQ QDMEQYLSTG YLQIAERREP IGSMSSMEVN VDMLEQMDLM DISDQEALDV FLNSGGEENT VLSPALGPES STCQNEITLQ VPNPSELRAK PPSSSSTCTD SATRDISEGG ESPVVQSDEE EVQVDTALAT SHTDREATPD GGEDSDS
Molecular weight:
(307 aa)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 0.5 mM DTT, 20% glycerol
Purity:
>95% by SDS - PAGE
State:
Liquid purified protein
Purified
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