AR09964PU-S EIF2B1 / EIF2BA (1-305, His-tag)

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10 µg / €300.00
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EIF2B1 / EIF2BA

AR09964PU-S

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  • AR09964PU-S

Product Description for EIF2B1 / EIF2BA

EIF2B1 / EIF2BA.
Presentation: Purified

Properties for EIF2B1 / EIF2BA

Product Category Proteins & Growth Factors
Target Category
Quantity 10 µg
Synonyms Translation initiation factor eIF-2B subunit alpha, eIF-2B GDP-GTP exchange factor subunit alpha
Presentation Purified
Molecular weight 35.8 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q14232
Purity > 90 %
Background EIF2B1 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Phosphorylation of eIF2 inhibits GEF activity of EIF2B, an inhibition that requires the eIF2B1 subunit. Defects in eIF2B1 are a cause of leukoencephalopathy with vanishing white matter (VWM), a brain disease that is characterized by head trauma and motor deterioration.
Concentration 0.5 mg/ml (determined by Bradford assay)
General Readings Van der Knaap M.S. et al. (2002) Ann. Neurol 51: 264-270.
Mohammad-Qureshi S.S. et al. (2007) Mol. Cell. Biol. 27: 5225-5234.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human EIF2B1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL IKLYL
Molecular weight:
(325aa) confirmed by MALDI-TOF
Format
Buffer System:
20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl
Purity:
>90%
State:
Liquid purified protein
Purified
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