Product Description for Fibroblast Growth Factor acidic (FGF-1)
Properties for Fibroblast Growth Factor acidic (FGF-1)
|Product Category||Proteins & Growth Factors|
|Molecular weight||15.8 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 95 % Greater than 95.0% as determined by: (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE|
|Background||Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis.
Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
|Concentration||1 mg/ml (before lyophilization)|
|General Readings||1. Effects of a Single Percutaneous Injection of Basic Fibroblast Growth Factor on the Healing of a Closed Femoral Shaft Fracture in the Rat.
Calcif Tissue Int 2007 Jul 19;
2. Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma.
Oncogene 2007 Jul 16;
3. Relevance of Partially Structured States in the Non-Classical Secretion of Acidic Fibroblast Growth Factor.
Biochemistry 2007 Jul 18;
4. Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease.
Semin Dial 2007 Jul-Aug;20(4):302-8
5. Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells.
Am J Physiol Renal Physiol 2007 Jul 18;
6. Human Fibroblast Growth Factor Receptor 1-IIIb Is a Functional Fibroblast Growth Factor Receptor Expressed in the Pancreas and Involved in Proliferation and Movement of Pancreatic Ductal Cells.
Pancreas 2007 Aug;35(2):147-157
|Storage||Lyophilized FGF-acidic although stable at room temperature for 3 weeks, should be stored desiccated below -18°C.
Upon reconstitution FGF-acidic should be stored at 4°C between 2-7 days and for future use below -18°C. Please avoid freeze-thaw cycles. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).